Collection of Blood for Gene Expression/Genomic Studies in Individuals With Chronic Lung Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 3,087
- 试验地点
- 1
- 主要终点
- Establish a set of normal ranges for various parameters in healthy individual specimens and compare to specimens from individuals with lung disease to determine parameters resulting in disease susceptibility and severity.
研究概览
简要总结
This is a research study where researchers are collecting blood to evaluate the genetic characteristics of individuals with chronic lung diseases, including asthma, chronic obstructive pulmonary disease (COPD), interstitial lung disease, cystic fibrosis, and lung cancer.
详细描述
The investigators hope to be able to identify an association between a genetic make-up in the blood samples and the risks of developing a particular lung disease, or severity of a lung disease. The findings of this study might be important to develop future preventative methods and potential treatments for the management of lung disease. The investigators aim to collect blood samples from 300 people with lung disease and 300 controls over 5 years.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Must provide informed consent
- •Males and females, age 18 years and older
- •Lung disease proven by at least one of the following:
- •symptoms consistent with pulmonary disease
- •chest X-rays consistent with lung disease
- •pulmonary function tests consistent with lung disease
- •lung biopsy consistent with lung disease
- •family history of lung disease
- •disease of organs with know associated with lung disease
- •individuals suspected of history of lung disease based on history and/or physical examination
- •normal controls (individuals without history of lung disease) to be sampled to provide a comparison to the lung disease cohort.
排除标准
- •Drug and/or alcohol abuse within the past six months
- •Females who are pregnant or nursing
结局指标
主要结局
Establish a set of normal ranges for various parameters in healthy individual specimens and compare to specimens from individuals with lung disease to determine parameters resulting in disease susceptibility and severity.
时间窗: 5 years
次要结局
未报告次要终点