Catheter Ablation of Ventricular Arrhythmia Reduces Skin Sympathetic Activity
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Ventricular Tachycardia
- Sponsor
- Mayo Clinic
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- Change in LF/HF ratio
- Status
- Terminated
- Last Updated
- last year
Overview
Brief Summary
This study is being done to determine whether there is an increase in sympathetic nerve activity before the onset of ventricular arrhythmias or irregular heartbeat rhythm. In addition, this study is looking at the relationship between sympathetic nerve activity and how patients with ventricular arrhythmias respond to catheter ablation treatment.
Investigators
Yong-Mei Cha
Principal Investigator
Mayo Clinic
Eligibility Criteria
Inclusion Criteria
- •Patients who have non-sustained or sustained VA (VA ≥ 30s or receiving appropriate ICD therapies) are presented to the clinic or admitted to the hospital within 7 days of episodes.
- •The causes of VA are associated with structural heart diseases including ischemic or nonischemic cardiomyopathy (idiopathic cardiomyopathy, hypertrophic cardiomyopathy, cardiac sarcoidosis or amyloidosis, and arrhythmogentic right ventricular dysplasia).
- •Subjects are 18 years of age and older.
Exclusion Criteria
- •Female patients who is pregnant or of childbearing potential and not on a reliable form of birth control.
- •Allergic to skin patch electrodes.
- •Vulnerable populations (fetuses, neonates, pregnant women, prisoners, institutionalized individuals).
Outcomes
Primary Outcomes
Change in LF/HF ratio
Time Frame: Baseline, 24 hours post catheter ablation and approximately 3-6 months post-operative
low frequency (LF)/high frequency (HF) ratio of the skin sympathetic nerve activity
Change in amplitude of skin sympathetic nerve activity
Time Frame: Baseline, 24 hours post catheter ablation and approximately 3-6 months post-operative
measured in µV