Catheter Ablation of Ventricular Arrhythmia Reduces Skin Sympathetic Activity

Terminated

• Conditions: Ventricular Tachycardia

• Registration Number: NCT04837183
• Lead Sponsor: Mayo Clinic

Brief Summary

This study is being done to determine whether there is an increase in sympathetic nerve activity before the onset of ventricular arrhythmias or irregular heartbeat rhythm. In addition, this study is looking at the relationship between sympathetic nerve activity and how patients with ventricular arrhythmias respond to catheter ablation treatment.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2021-03-16
• Study First Submitted QC: 2021-04-06
• Study First Posted: 2021-04-08
• Study Start: 2021-11-15
• Primary Completion: 2024-01-01
• Study Completion: 2024-01-01
• Status Verified: 2024-06
• Last Update Submitted: 2024-06-29
• Last Update Posted: 2024-07-03

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Patients who have non-sustained or sustained VA (VA ≥ 30s or receiving appropriate ICD therapies) are presented to the clinic or admitted to the hospital within 7 days of episodes.
• The causes of VA are associated with structural heart diseases including ischemic or nonischemic cardiomyopathy (idiopathic cardiomyopathy, hypertrophic cardiomyopathy, cardiac sarcoidosis or amyloidosis, and arrhythmogentic right ventricular dysplasia).
• Subjects are 18 years of age and older.

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Exclusion Criteria

• Female patients who is pregnant or of childbearing potential and not on a reliable form of birth control.
• Allergic to skin patch electrodes.
• Vulnerable populations (fetuses, neonates, pregnant women, prisoners, institutionalized individuals).

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in LF/HF ratio	Baseline, 24 hours post catheter ablation and approximately 3-6 months post-operative	low frequency (LF)/high frequency (HF) ratio of the skin sympathetic nerve activity
Change in amplitude of skin sympathetic nerve activity	Baseline, 24 hours post catheter ablation and approximately 3-6 months post-operative	measured in µV

Trial Locations

Locations (1)

Mayo Clinic in Rochester; 🇺🇸 Rochester, Minnesota, United States