Evaluation of drug Dexmedetomidine as part of anaesthetic regimen during conduct of brain tumor surgery.

Completed

• Conditions: Cerebello-pontine angle tumour patients

• Registration Number: CTRI/2017/01/007667

Brief Summary

Cerebello-pontine angle (CPA) surgeries tend tocarry the surgeon’s knife uncomfortably close to the brainstem, putting variouscranial nerves at risk for damage. For preventing this, cranial nerve monitoringusing continuous electromyography (EMG) of the regional motor supply of thenerve or evoked potentials is utilized. It has been recommended in literature that propofolas a primary hypnotic component of anaesthesia would provide better conditionsfor cranial nerve monitoring compared to inhalational agents. High dose of propofol has certain undesirableeffects as such as occasional delayed awakening, metabolic acidosis withincreased lactate levels and myocardial depression causing hypotension. Dexmedetomidine has been used as an anaesthetic adjunct to propofol and has been shown to reduce propofol requirements, whenused along with processed EEG monitoring. Inthis study, we propose to quantify the probable dose reduction of propofol withuse of dexmedetomidine during CPA surgeries and compare the recovery profile,adequacy of cranial nerve monitoring, acid base status and intraoperative haemodynamicswith and without the usage of dexmedetomidine.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-06-15
• Last Update Posted: 2017-10-01

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 48

Inclusion Criteria

Patients undergoing Cerebello-pontine angle surgeries with cranial nerve monitoring.

Exclusion Criteria

• 1)Patients with evidence of sino-atrial nodal or atrio-ventricular nodal bradyarrhythmia on ECG, baseline heart rate < 50/min.
• 2)Patients with known history of hypertension and being treated with anti-hypertensive drugs.
• 3)Patients on tricyclic antidepressant, clonidine, monoamine oxidase-inhibitor therapy.
• 4)Patients with evidence of impaired hepatic/renal function according to past history or preoperative biochemistry parameters.
• 5)Need for intraoperative inotrope/vasopressor drug.
• 6)Allergy to egg/propofol 7)Absence of cranial nerve monitoring during surgery.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Quantification of anaesthetic and analgesic sparing effect of dexmedetomidine.	End of anaesthesia.

Secondary Outcome Measures

Name	Time	Method
1)Recovery from anaesthesia based on time to opening eyes, time to following commands and time to extubation after anaesthetic withdrawal.	2)Evaluate the effect propofol alone and propofol-dexmedetomidine combination on acid base status.

Trial Locations

Locations (1)

Bangalore; 🇮🇳 Bangalore, KARNATAKA, India

Bangalore

🇮🇳Bangalore, KARNATAKA, India

Dr Dhritiman Chakrabarti

Principal investigator

8197781240

rosesrred90@gmail.com