Effect of dexmedetomidine on eye and venous pressure in patients undergoing elective neurosurgical procedure.

Not yet recruiting

Conditions: Medical and Surgical,

Registration Number: CTRI/2021/09/036111

Lead Sponsor: Department of anaesthesiology and critical care

Brief Summary: The goals of neuroanesthesia are to ensure stable peri operative cerebral hemodynamics and avoid sudden rise in intracranial pressure to prevent acute swelling. Rised intracranial pressure ice is usually morbidity, mortality, and poor neurological outcomes. Raised intracranial pressure can arise from intracranial SOL and nontraumatic origin.

Monitoring of intracranial pressure therefore becomes necessary in patients

Presenting with the space occupying lesions. Invasive intracranial pressure monitoring is gold standard but it is associated with complications.

The use of bedside ocular ultrasonography in measuring optic nerve sheath diameter can be useful method for defecting raised intracranial pressure.It has the advantage of being a noninvasive,portable and easily preformed approach.

Dexmedetomidine is a highly selective alpha -2 adrenoreceptor agonist recently introduced in anesthesia practice . It produces dose dependent sedation,anxiolytics and analgesia without respiratory depression.

This study is therefore designed to evaluate the effect of Dexmedetomidine as an anesthetiser adjuvant on the size of optic nerve sheath diameter and central venous pressure in elective neurological procedures

The goals of neuroanesthesia are to ensure stable peri operative cerebral hemodynamics and avoid sudden rise in intracranial pressure to prevent acute swelling. Rised intracranial pressure ice is usually morbidity, mortality, and poor neurological outcomes. Raised intracranial pressure can arise from intracranial SOL and nontraumatic origin.

Monitoring of intracranial pressure therefore becomes necessary in patients

Presenting with the space occupying lesions. Invasive intracranial pressure monitoring is gold standard but it is associated with complications.

The use of bedside ocular ultrasonography in measuring optic nerve sheath diameter can be useful method for defecting raised intracranial pressure.It has the advantage of being a noninvasive,portable and easily preformed approach.

Dexmedetomidine is a highly selective alpha -2 adrenoreceptor agonist recently introduced in anesthesia practice . It produces dose dependent sedation,anxiolytics and analgesia without respiratory depression.

This study is therefore designed to evaluate the effect of Dexmedetomidine as an anesthetiser adjuvant on the size of optic nerve sheath diameter and central venous pressure in elective neurological procedures.

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: Not specified

Target Recruitment: 40

Inclusion Criteria

Written informed consent ASA 1 and 2 Age.
60 years Gender -male and female Patients with elective neurosurgical procedures.

Exclusion Criteria

No extended intracranial pressure but increased optic nerve diameter.
Optic nerve disease such as optic neuritis , Arachnoid cyst of optic nerve.
Anterior orbital or cavernous sinus mass.
Known orbital injury or prior ocular surgery.
Histroy of allergy to alpha 2 agonists.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To assess the effect of dexmedetomidine as an anaesthetic adjuvant on optic nerve sheath diameter (ONSD) in adult patients.	10 months
To assess the effect of dexmedetomidine as an anaesthetic adjuvant on central venous pressure (CVP) in adult patients undergoing elective neurosurgical procedures.	10 months

Secondary Outcome Measures

Name	Time	Method
To find the correlation between ONSD and CVP in adult patients undergoing elective neurosurgical procedures.	Documentation of side effects -nausea , vomiting , hypotension, bradycardia,during and after surgery.

Trial Locations

Locations (1): JNMCH,AMU
🇮🇳
Aligarh, UTTAR PRADESH, India
JNMCH,AMU
🇮🇳Aligarh, UTTAR PRADESH, India
Karishma
Principal investigator
8360348105
karishmasinha1511@gmail.com