Analyzing Acoustic Properties of the Vowel "a" Collected Via Mobile Phone From Individuals Diagnosed With Chronic Obstructive Pulmonary Disease and Health Control Groups

Active, not recruiting

• Conditions: Chronic Obstructive Pulmonary Disease

• Registration Number: NCT06705647
• Lead Sponsor: Blekinge Institute of Technology

Brief Summary

The Study aims to identify the changes in voice caused by Chronic Obstructive Pulmonary Disease (COPD) statistically for identifying the potential digital voice biomarkers.

Detailed Description

1058 voice recordings collected via mobile phones over time in form of the Swedish utterance of vowel "a" will be analysed using vowel quadrilateral space and the Mann-Whitney U test.

The significance threshold p-value will be set to 0.05, and vocal features consisting of 101 base line acoustic features and MFCC features will be analysed between the COPD and HC groups. The most significant features that remain under the significance threshold will be reported.

Study Timeline

• Study Start: 2024-10-28
• Status Verified: 2024-11
• Study First Submitted: 2024-11-22
• Study First Submitted QC: 2024-11-25
• Last Update Submitted: 2024-11-25
• Study First Posted: 2024-11-26
• Last Update Posted: 2024-11-26
• Primary Completion: 2025-02-28
• Study Completion: 2025-03-30

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 48

Inclusion Criteria

• being 18 years old and older.

Exclusion Criteria

• being under 18 years old and older.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Difference in Acoustic Voice Features Between COPD and Healthy Control Participants Difference in Acoustic Voice Features Between COPD and Healthy Control Participants	30 weeks	This study assesses differences in baseline acoustic features (e.g., F0, HNR, jitter, shimmer, and formant frequencies), MFCC features (1-13 and derivatives Δ, ΔΔ), and vowel quadrilateral metrics (VSA from F1 and F2 of the sustained vowel 'a') between COPD and healthy controls. Acoustic features are extracted using Parselmouth and Praat, while MFCC features are computed with Librosa. Descriptive statistics (median, mean, std) are calculated, and group differences are tested for significance using the Mann-Whitney U test. Units include median, mean, std for each feature and VSA (Hertz²). Results will include p-values for group comparisons.

Trial Locations

Locations (1)

Blekinge Institute of Technology; 🇸🇪 Karlskrona, Blekinge, Sweden