The effect of preconditioning of sevofluran in cardiac ischemia
Phase 2
- Conditions
- Preconditioning of heart during coronary artery bypass surgery.Unspecified complication of cardiac and vascular prosthetic device, implant and graft
- Registration Number
- IRCT2016061528477N1
- Lead Sponsor
- Boushehr Medical Scinces University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
All elective coronary bypass surgery in patients 40 to 80 years old.
Exclusion criteria: AV block(mobitz2); complete Heart block; LBBB;
Acute heart failure(EF<30); Reexploration after surgical complications
; MI in last 7 days ago.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Troponin I blood level. Timepoint: At entrance to ICU and after 4,8,24,48 hours from coronary bypass surgery. Method of measurement: µg / l0.01 SI unit.;Electrocardiography. Timepoint: ECG changes at entrance to ICU and daily up to 4 days. Method of measurement: Electrocardiography device.;Nuclear heart scan. Timepoint: 3 nuclear heart scan befor CABG and 1 and 6 month after surgery. Method of measurement: SPECT-CT Scan.
- Secondary Outcome Measures
Name Time Method Systolic blood pressure. Timepoint: Before anesthesia induction, one minute after off pump, one hour after off pump, 8 and 24 hour after surgery. Method of measurement: Heart Monitoring.;Diastolic blood pressure. Timepoint: Before anesthesia induction, one minute after off pump, one hour after off pump, 8 and 24 hour after surgery. Method of measurement: Heart Monitoring.;Mean arterial pressure. Timepoint: Before anesthesia induction, one minute after off pump, one hour after off pump, 8 and 24 hour after surgery. Method of measurement: Heart Monitoring.;Heart rate. Timepoint: Before anesthesia induction, one minute after off pump, one hour after off pump, 8 and 24 hour after surgery. Method of measurement: Heart Monitoring.