Ultrasound-Guided Thoracic Paravertebral Block With Steroid and Local Anesthetic for Acute Herpes Zoster: Effects on Pain Control and Prevention of Postherpetic Neuralgia: A Randomized Controlled Trial
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 入组人数
- 100
研究概览
简要总结
Background: Acute herpes zoster causes severe neuropathic pain and may progress to postherpetic neuralgia (PHN). This study aims to evaluate ultrasound-guided thoracic paravertebral block with local anesthetic and steroid in reducing acute pain and PHN incidence.
Methods: This prospective randomized study included 100 patients diagnosed with acute thoracic herpes zoster (rash ≤14 days, NRS ≥4). Participants were allocated into two groups: a control group receiving standard medical treatment and an intervention group receiving standard treatment in addition to an ultrasound-guided thoracic paravertebral block with (0.25% bupivacaine + 40 mg methylprednisolone) at 48-72-hour intervals. Pain intensity was assessed at baseline and during follow-up. The incidence of postherpetic neuralgia was recorded. Secondary outcomes included analgesic consumption and patient satisfaction.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 45 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Eligibility Criteria Inclusion Criteria
- •Age 45-65 years
- •Diagnosed with acute thoracic herpes zoster
- •Rash duration ≤ 14 days
- •Moderate to severe pain, defined as NRS ≥ 4
- •Total sample size: 100 patients
排除标准
- •Contraindications to thoracic paravertebral block, including:
- •Coagulopathy
- •Infection at the injection site
- •Allergy to local anesthetics or steroids
- •Immunosuppression or ongoing chemotherapy
- •Pre-existing chronic pain in the same affected region
- •Severe cognitive impairment or psychiatric illness preventing reliable pain assessment
- •Pregnancy or lactation
研究者
Marwa mahmoud Abd El Rady
clinical proffessor
Assiut University