OPTIMIZING PERIPHERAL CIRCULATION WITH VASODILATOR THERAPY IN CRITICALLY ILL PATIENTS WITH CIRCULATORY SHOCK: A PILOT STUDY
- Conditions
- circulatory shockdisease of circulatory system
- Registration Number
- NL-OMON44686
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 177
Inclusion Criteria
All consecutive adult patients admitted to the intensive care for circulatory shock resuscitation in whom abnormal peripheral perfusion is still present despite normalization of global hemodynamic parameters are eligible for this study.
Exclusion Criteria
Liver failure, severe coagulation disorder, and any neurological insult that could lead to increased intracranial pressure (stroke, subarachnoid haemorrhage, brain trauma injury).
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Capillary refill time (s), skin-difference temperature gradient (0C),<br /><br>peripheral perfusion index (a.u.), resting peripheral tissue oxygenation (StO2)<br /><br>values (%), rate of StO2 desaturation (%/min), rate of StO2 recovery (%/s),<br /><br>sublingual microcirculation parameters [total vessel density (mm/mm2), perfused<br /><br>vessel density (mm/mm2), and vessel diameters (µm), red blood cell velocity<br /><br>(µm /sec), proportion of perfused vessels (%), microvascular flow index (a.u.),<br /><br>and flow heterogeneity (a.u.)], gastric perfusion parameters (gastric mucosa<br /><br>CO2 and EtCO2 difference).</p><br>
- Secondary Outcome Measures
Name Time Method <p>Global hemodynamic parameters: Fluid balance, mean arterial pressure (MAP),<br /><br>central venous pressure (CVP), central venous oxygen saturation (ScvO2),<br /><br>cardiac output and stroke volume, blood lactate levels.<br /><br>Respiratory function: arterial oxygen pressure/inspired oxygen fraction ratio<br /><br>(PaO2/FiO2 ratio), mechanical ventilation free-days.<br /><br>Other study parameters: length of ICU stay , Sequential organ failure<br /><br>assessment score (SOFA), Acute Physiological and Chronic Health Evaluation<br /><br>score (APACHE II).</p><br>