Effects of Chinese Medicine on Early Pregnant Women
- Conditions
- Pregnant Women
- Registration Number
- NCT04848571
- Brief Summary
From April 2021 to December 2021, 45 pregnant women who received intro fertilization-embyro transfer (IVF-ET) were recuited. According to their own wishes, 28 of them took Chinese medicine from the 2nd week after embryo transfer (intervention group), while the remaining 17 did not intake Chinese medicine (control group). Blood and feces samples were collected in the early morning of the 4th week after embryo transfer to detect 16S DNA sequences in feces, plasma metabolites, and whole blood transcriptomics.
- Detailed Description
Investigators planned to performed a observational clinical trial to determine the effects of the Chinese medicine (Gushen Antai recipe) including mainly Rehmannia glutinosa used in pregnant women for fetal protection. Two groupswere recruited, Chinese medicine intervention group and control group without Chinese medicine. In the 4th week after embryo transfer, blood and fetal were sampled for metabolic and intestinal microbiota analysis.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 45
- recieved IVF
- childbirth without miscarriage
- taking vitamins during pregnancy
- miscarrige
- missed sampling in the fourth week of pregnancy
- not appropriate judged by the doctor
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 16s DNA analysis in feces the fourth week in early pregnancy intestinal flora analysis in patients
- Secondary Outcome Measures
Name Time Method plasma metabonomics analysis by GC/LC mass the fourth week in early pregnancy plasma metabolic analysis in patients
Trial Locations
- Locations (1)
Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine
🇨🇳Shanghai, China
Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine🇨🇳Shanghai, China