Targeting systemic inflammation to improve endothelial function in obesity

Phase 4

Completed

• Conditions: Topic: Cardiovascular; Subtopic: Cardiovascular (all Subtopics); Disease: Cardiovascular; Nutritional, Metabolic, Endocrine; Obesity

• Registration Number: ISRCTN14884558
• Lead Sponsor: niversity of Leeds (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2011-06-10
• Study Completion: 2012-02-01
• Last Update Posted: 30 May 2022

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

1. Age 18-65
2. Obesity (Body Mass Index 30 or greater)
3. Not taking other medication (apart from oral contraceptives)
Target Gender: Male & Female; Upper Age Limit 65 years ; Lower Age Limit 18 years

Exclusion Criteria

1. Diabetes
2. Hypertension
3. Hyperlipidaemia
4. Cardiovascular disease or history of cardiac arrythmias
5. Chronic inflammatory disorders (e.g. rheumatoid arthritis, connective tissue disorders, gout, inflammatory bowel
disease, chronic infections)
6. Acute inflammatory illnesses (e.g. upper respiratory tract infections)
7. Allergy to pentoxifylline or other methyl xanthine drugs or concomitant use of sildenafil, tadalafil, vardenafil or other phosphodiesterase inhibitors
8. History of cerebral haemorrhage or retinal haemorrhage
9. Pregnancy or breastfeeding
10. Impaired renal function

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Flow mediated dilatation of brachial artery (%); Timepoint(s): at end of treatment period

Secondary Outcome Measures

Name	Time	Method
ot provided at time of registration