Cognition in classic galactosemia: What happens to the developing brain?

Completed

• Conditions: Classic Galactosemia; inherited metabolic disorder; 10021605

• Registration Number: NL-OMON32979
• Lead Sponsor: Academisch Ziekenhuis

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 11 June 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 52

Inclusion Criteria

A diagnosis of classic galactosemia as assessed by GALT enzyme activity assay or GALT-gene mutation analysis (information obtained from treating physician)
Age between 10 and 18 years old

Exclusion Criteria

Any other disorder or disease that could affect cognitive functioning independently of classic galactosemia (an exception is made for the diagnosis of Attention-Deficit/Hyperactivity Disorder (ADHD), because this disorder is common in this group)

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main parameters are 1) the performance on the speech-related behavioural<br /><br>paradigms (four paradigms, each focusing on one aspect of speech processing or<br /><br>production) and; 2) the event-related potentials (ERPs) extracted from the EEG<br /><br>recorded during the behavioural tasks.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The secundary parameter is the performance on the neuropsychological<br /><br>testbattery (i.e. a composition of tests focusing on the major cognitive<br /><br>domains: memory, attention, speech and language, visuo-motor skills).</p><br>