Prevalence of Wild Type Transthyretin Cardiac Amyloidosis in Patients Operated for Idiopathic Carpal Tunnel Syndrome
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 120
- 试验地点
- 2
- 主要终点
- Prevalence of cardiac amyloidosis.
研究概览
简要总结
Wild-type transthyretin cardiac amyloidosis is an underdiagnosed depository disease in which fibril monomers of misfolded amyloid protein accumulates in various tissues, including the heart, and cause tissue dysfunction.
Before onset of cardiac symptoms, many patients will have undergone surgery for idiopathic carpal tunnel syndrome since the protein also deposits in the transversal carpal ligament of the hand.
This study investigates patients previously operated for idiopathic carpal tunnel syndrome to determine if they display signs and symptoms of cardiac amyloidosis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 60 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients above sixty years of age previously operated for idiopathic carpal tunnel syndrome within the Region of Central Denmark (Region Midtjylland) the last five years.
- •Informed written and verbal consent
排除标准
- •Operation by different indication such as
- •Osteophytes
- •Rheumatoid Arthritis
- •Persistent medial artery
- •Metabolic causes
- •Alcoholism
- •Hyperthyroidism
- •Hereditary Cardiac Amyloidosis
- •Known WT ATTR
- •AL Amyloidosis
- •Myelomatosis
- •MGUS and Morbus Waldenström
结局指标
主要结局
Prevalence of cardiac amyloidosis.
时间窗: Through study completion, an average of 2 years.
The prevalence of cardiac amyloidosis among patients previously operated for ipiopathic carpal tunnel syndrome.
次要结局
未报告次要终点
研究者
Steen Hvitfeldt Poulsen
Professor
Aarhus University Hospital Skejby