Effects of Different I:E Ratio on Intrapulmonary Shunt Fraction and Oxygenation During One Lung Ventilation in the Lateral Decubitus Position

Not Applicable

Completed

• Conditions: Lung Lobectomy; Lung Cancer

• Registration Number: NCT01499212
• Lead Sponsor: Yonsei University

Brief Summary

The purpose of this study is to investigate effect of increasing inspiratory time (I:E ratio 1:1) on intrapulmonary shunt fraction and oxygenation during one lung ventilation in the lateral decubitus position.

Detailed Description

Increasing inspiratory time(e.g. Inverse ratio ventilation) has been known that had advantage of alveolar recruitment, preventing of ateletasis. On the contrary, it has disadvantange of intrinsic PEEP, air trapping. There is few study on one lung ventilation in lateral decubitus position about this ventilation method. We were going to investigate effecf of this ventilation method.

Study Timeline

• Study Start: 2011-07
• Primary Completion: 2011-11
• Status Verified: 2011-12
• Study Completion: 2011-12
• Study First Submitted: 2011-12-18
• Study First Submitted QC: 2011-12-21
• Last Update Submitted: 2011-12-21
• Study First Posted: 2011-12-26
• Last Update Posted: 2011-12-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 58

Inclusion Criteria

• ASA physical status class I, II
• Use of Double lumen tube
• Unilateral lung lobectomy

Exclusion Criteria

• COPD
• CAOD
• Unstable hemodynamic status
• Peak airway pressure > 30mmHg (Two lung ventilation)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
intrapulmonary shunt fraction	T1 (10min before one lung ventibation)T2 (30min after one lung ventilation started)T3 (60min after one lung ventilation started)T4 (10min after two lung ventilation)	T1,T2,T3,T4 : ALL mesurement in lateral decubitus position T1-intrapulmonary shunt T2-intrapulmonary shunt T3-intrapulmonary shunt T4-intrapulmonary shunt

Secondary Outcome Measures

Name	Time	Method
Respiratory dynamic parameters	T1,T2,T3,T4 (same as primary outcome measure)	Mechanical Ventilator measurement : Paw, Pplat, Pmean, Compliance

Trial Locations

Locations (1)

Department of Anaesthesiology and Pain Medicine, Anaesthesia and Pain Research Institute, Yonsei University College of Medicine; 🇰🇷 Seoul, Korea, Republic of