Dynamic Whole-body PET/CT Imaging in Clinical Oncology
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- Standard SUV measurement metric
研究概览
简要总结
The goal of this clinical trial is to to achieve robust quantitative whole- body parametric imaging in clinically feasible scan times in patient with oncologic pathology .
The main question[s] it aims to answer are:
- [question 1]
- [question 2] Participants will [describe the main tasks participants will be asked to do, treatments they'll be given and use bullets if it is more than 2 items].
详细描述
Whole body hybrid PET/CT imaging, making use of the standardized uptake value (SUV), is well established in clinical setting for diagnosis and staging, treatment response monitoring and radiation therapy treatment planning of a wide range of oncologic malignancies. However, the SUV metric derived from static PET data does not capture the dynamics of the PET probe biodistribution in the body.
The present work proposes to fill in this notable gap: namely to merge whole-body and dynamic PET/CT imaging, to achieve robust quantitative whole- body parametric imaging in clinically feasible scan times. Our proposed approach has the potential to significantly enhance diagnostic, prognostic and treatment response monitoring capabilities of PET/CT and to fundamentally alter routine clinical practice.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients clinically indicated for whole-body PET evaluation.
- •Patient must agree to lie still in the camera.
- •Patient must be able to comply with study procedures.
- •Patient must be able to provide informed consent.
排除标准
- •Patients < 18 years of age.
- •Pregnant women are excluded.
结局指标
主要结局
Standard SUV measurement metric
时间窗: through study completion , an average of 2 years
The standard SUV measurement metric will be compared with the measured influx rate Ki as obtained from dynamic PET/CT imaging for FDG-avid processes. We expect a correlation coefficient of at least 0.8.
次要结局
- Image quality(through study completion , an average of 2 years)
- Certainty in diagnosis of FDG-avid processes(through study completion , an average of 2 years)
研究者
Valentina Garibotto
Head of the Division of Nuclear Medicine and Molecular imaging
University Hospital, Geneva