Dynamic whole body data acquisition in PET/CT diagnostics: a prospective data collection in clinically indicated examinations

Not Applicable

Suspended

Conditions: Oncological diseases.Inflammatory forms of disease (e.g. fever of unclear origin, vasculitis, spondylodiscitis or unclear inflammation in the chest / pulmonary etc.)
C15.9
C43
C83
C14
C32
C80
C19
C53
C54

Registration Number: DRKS00021217

Lead Sponsor: niversitätsklinikum Tübingen, Radiologische Klinik, Nuklearmedizin & Klinische Molekulare Bildgebung

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Suspended

Sex: All

Target Recruitment: 300

Inclusion Criteria

• Clinical indication for a PET/CT examination
• Patients with a malignant or inflammatory disease
• Patients who are able to understand the nature and scope of the pseudonymized, prospective data collection
• Patients who tolerate 80 min measuring time in the PET/CT scanner
• Age =18 years
• Written consent of the patient

Exclusion Criteria

• Pregnant and lactating women,
• Patients with claustrophobia,
• Patients with problems/pain when lying on their back, who may not tolerate a measurement time of more than one hour,
• Exclusion criteria according to the Radiation Protection Ordinance (StrlSchV),
• The patient's limited ability to consent.

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The primary goal of this study is to collect dynamic PET parameters (Ki, DV, K1 and Vb) from the primary tumor, lymph node regions, distant metastases, inflammatory tissues and reference organs and to correlate them with clinically indicated follow-up examinations or histopathological analyzes (gold standard”).

Secondary Outcome Measures

Name	Time	Method
• Differentiation of inflammatory and tumor-associated tissue changes using suitable dynamic PET parameters,<br>• Investigation of of PET tracer kinetics in tumorous, inflammatory and healthy tissue and organs,<br>• Correlation of dynamic parameters with semi-quantitative measurements of static images,<br>• Assessment of the response of chemotherapy, immunotherapy and modulators, radiotherapy and radio peptide therapies,<br>• Optimization of the workflow for dynamic wb-PET/CT and shortened dynamic whole body imaging,<br>• Shortening of the dynamic examination protocol by correlation with the activity from venous blood samples.