Comparison of renal sympathetic denervation with spironolactone in patients with still a high blood pressure despite the use of 3 different antihypertensive agents.
Recruiting
- Conditions
- Hypertension, Renal sympathetic denervation, Sprionolactone. Hypertensie, Renale sympathische denervatie, spironolacton
- Registration Number
- NL-OMON26106
- Lead Sponsor
- Erasmus MC: Department of Radiology
- Brief Summary
M. Ezzahti, A. Moelker, A.H. van den Meiracker: Endovascular renal sympathetic denervation. A new treatment for treatment resistant hypertension? Hart Bulletin 2012;43:34-39.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 120
Inclusion Criteria
1. Age > 18 yrs and < 75 yrs;
2. Treatment-resistent hypertension;
Exclusion Criteria
1. Secondary hypertension;
2. Renal arteries inaccessible for endovascular denervation;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Difference in 24-hour ambulatory blood pressure between spironolactone and endovascular renal denervation 6 months after intervention.
- Secondary Outcome Measures
Name Time Method 1. Proportion of patients with normalisation of ambulatory blood pressure in the two intervention groups;<br /><br>2. Proportion of patients per intervention group with a decrease in 24-hour ambulatory blood pressure of at least 10 mmHg systolic and and at least 5 mmHg diastolic;<br /><br>3. Predictive value of clonidin-suppression test on blood pressure response to endovascular sympathetic denervation;<br /><br>4. Cost effectiveness of renal sympathetic denervation;<br /><br>5. Difference in quality of life score between endovascular renal denervation and spironolactone group.