Exhaled Breath profiling by an Electronic Nose in the Diagnosis of Pulmonary Sarcoidose

• Conditions: Lung sarcoidosis; 10003816; 10038716

• Registration Number: NL-OMON35021
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 120

Inclusion Criteria

* Adult patients, between 18-70 years old, with a confirmed diagnosis of sarcoidosis. (Diagnosis of sarcoidosis according to the generally accepted consensus criteria.)
* Treatment naïve patients. A low dose oral prednisolone (< 10 mg daily) will be allowed.

Exclusion Criteria

* Patients with underlying conditions with an established effect on the exhaled VOCs.
* Any other respiratory disease except sarcoidosis and/or any systemic diseases.
* Respiratory tract infections requiring antibiotics and/or oral steroids in the 4 weeks prior to the study will be excluded.
* Current and ex tobacco Smoking. (However, patients with a smoking history of < 1 packyear and no smoking during the past 10 years can be included).
* Prior diagnosis of malignancies

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Smellprint of sarcoidosis patients versus controls.<br /><br>Smellprint of patients with different radiological stages.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Hypothesize that an electronic nose can discriminate between different stages<br /><br>of pulmonary sarcoidosis (sub-phenotyping)<br /><br>Finally we aim to characterize VOCs in samples detected by the electronic nose<br /><br>by gas-chromatography and mass-spectrometry</p><br>