the Application of Exhaled breath aNalysis in the Early detection of ASpergillosis
- Conditions
- Invasive aspergillosis
- Registration Number
- NL-OMON28185
- Lead Sponsor
- one.
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
Patients, aged 18 or older, that will undergo treatment for a hematological malignancy expected to result in grade 4 neutropenia for more than 7 days, e.g. hematopoietic stem cell transplantation or induction/consolidation treatment for acute myeloid leukaemia.
Exclusion Criteria
Previous invasive pulmonary mycosis.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The accuracy with which patients with probable or proven invasive pulmonary aspergillosis and neutropenic controls can be discriminated from each other with exhaled breath analysis using among other techniques GC-MS, as measured by the values of the sensitivity, specificity and accuracy.
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What volatile organic compounds (VOCs) in exhaled breath correlate with early-stage invasive aspergillosis detection?
How does exhaled breath analysis compare to galactomannan and PCR for diagnosing invasive aspergillosis in immunocompromised patients?
Which fungal biomarkers in exhaled breath are most predictive of Aspergillus species-specific infection in high-risk populations?
What are the sensitivity and specificity thresholds of breath VOC profiling for invasive aspergillosis in hematopoietic stem cell transplant recipients?
How do breath analysis technologies like GC-MS or e-noses advance non-invasive diagnostics for invasive fungal infections compared to traditional methods?