Exhaled breath analysis to diagnose acute lung injury.
- Conditions
- ARDS, non-invasive diagnostic tests, early detection, octaneDutch: ARDS, niet-invasieve diagnostische methoden, vroege detectie, octane
- Registration Number
- NL-OMON27817
- Lead Sponsor
- Amsterdam UMC, locatie AMC.
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 500
Inclusion Criteria
Intubated and mechanically ventilated for less than 48 hours.
Exclusion Criteria
•Patient is expected to be deceased within 24 hours.
•Exhaled breath collection deemed inappropriate by the attending physicians.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Exhaled breath concentration of octane, measure by compact gas-chromatography.
- Secondary Outcome Measures
Name Time Method •Volatile organic compounds in exhaled breath measured by gas-chromatography and mass-spectrometry. <br /><br>•Protein patterns in fluid from the heat-moist exchanger. <br /><br>•Non-invasive imaging techniques: <br /><br>oLung ultrasound <br /><br>oElectrical impedance tomography. <br /><br>•Lung injury prediction score.<br /><br>•ARDS as defined by the Berlin Definition<br /><br>•Therapeutic response in ARDS patients<br /><br>•ARDS phenotypes defined by clinical characteristics and by a biomarker profile of plasma biomarkers