The Effects of an Acute Bout of Exercise on Alcohol and Cocaine Craving - an fNIRS Study

Not Applicable

• Conditions: Substance Use Disorders
• Interventions: Other: Intense exercise; Other: Moderate exercise; Other: Reading

• Registration Number: NCT03502486
• Lead Sponsor: University of Basel

Brief Summary

The study is a crossover randomised controlled trial. Alcohol or cocaine dependent participants will be recruited from inpatient and outpatient psychiatric treatment centres, on the approval of their treating physician. A healthy control group will be recruited using online advertising. All participants will undergo each of three conditions in a randomised order; 1) 20 minutes of cycle ergometry at 50-60% of maximum heart rate; 2) 20 minutes of exercise at 70-80% of maximum heart rate; 3) 20 minutes of quiet reading. Immediately before and after each condition, participants will be asked to complete a computerised Stroop test, watch a film containing substance-related images, and self-report craving levels. During the Stroop test and film viewing, participants' neural activity will be measured via functional near-infrared spectroscopy

Detailed Description

The aim of this study is to examine whether, following acute exercise bouts at moderate and high intensities, reduced craving and increased inhibitory control can be observed in alcohol or cocaine dependent individuals. As the focus of this study is the potential of exercise to be integrated into treatment, individuals in treatment for their dependence, who have been abstinent for a short period, will be recruited.

Study Timeline

• Study Start: 2017-07-05
• Status Verified: 2018-04
• Study First Submitted: 2018-04-05
• Study First Submitted QC: 2018-04-17
• Study First Posted: 2018-04-18
• Last Update Submitted: 2018-04-19
• Last Update Posted: 2018-04-20
• Primary Completion: 2019-08
• Study Completion: 2020-11

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

For alcohol or cocaine dependent participants:

• meeting three or more of the DSM-IV criteria for substance dependence (as determined by treating physician);
• minimum of 20 days and maximum of 40 days abstinence from substance of dependence;
• able to understand and complete the informed consent;
• able to travel to study site independently, as confirmed by the treating psychiatrist;
• assessed for physical and mental fitness by treating physician and cleared to take part in the study;
• fewer than 3 hours of physical exercise or sport per week;

For healthy controls:

• fewer than 3 hours of physical exercise or sport per week;
• no history of problematic alcohol or illicit drug consumption.

Exclusion Criteria

• Pregnancy
• Questionable findings during resting ECG screen

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Intense Exercise	Intense exercise	20 minutes of cycle ergometry at 70 - 80% of heart rate max.
Moderate exercise	Moderate exercise	20 minutes of cycle ergometry at 50 - 60% of heart rate max.
Rest	Reading	20 minutes of seated reading.

Primary Outcome Measures

Name	Time	Method
Stroop test accuracy	Change from Baseline after 20 minute acute condition	Accuracy on Stroop test
Stroop test reaction time	Change from Baseline after 20 minute acute condition	Reaction time on Stroop test
Self-reported craving	Change from Baseline after 20 minute acute condition	Sum score on Alcohol Craving Questionnaire Short Form (scale range 12 to 84, higher scores representing greater craving) or Cocaine Craving Questionnaire - Brief (scale range 10 to 70, higher scores representing greater craving)
Cerebral oxygenation in prefrontal cortex	Change from Baseline after 20 minute acute condition	Functional near infrared spectroscopic imaging of hemodynamic activity in prefrontal cortex

Trial Locations

Locations (1)

Department of Sport, Exercise and Health, University of Basel; 🇨🇭 Basel, Switzerland