Comparison of two different regimen of insulin in children with diabetic ketoacidosis
Not Applicable
- Conditions
- Health Condition 1: E101- Type 1 diabetes mellitus with ketoacidosis
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
All children between 1 month to 12 years diagnosed as DKA - defined as blood glucose more than 200mg/dl with acidosis pH less than 7.3 or bicarbonate less than 15mEq/l and ketonuria(urine dipstick result more than or equal to 2+/ketonemia >3mmol/L)
Exclusion Criteria
All children diagnosed as DKA and started on insulin in other hospital
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1.To measure the rate of decrease in blood glucose until the level reaches 200mg/dl or less <br/ ><br>2) to assess the time taken for resolution of acidosis- normalisation of anion gapTimepoint: 1.enrollment will be done within one hour of admission <br/ ><br>2.intervention will start at the time of enrollment <br/ ><br>3. As per ISPAD guidelines, patient will be assessed every hour for measuring the rate of decrease of blood glucose and every 4 hours for resolution of acidosis
- Secondary Outcome Measures
Name Time Method To assess the incidences of complications like hypokalemia, hypoglycaemia and cerebral edemaTimepoint: 1.enrollment will be done within one hour of admission <br/ ><br>2.intervention will start at the time of enrollment <br/ ><br>3.As per ISPAD guidelines, patient will be assessed every hour for hypoglycemia and for cerebral edema <br/ ><br>4. patient will be assessed every fourth hour for hypokalemia