A pilot randomised controlled trial of antidepressant medication switching for treatment-refractory depression in primary care
- Conditions
- Depression, Treatment-resistantMental and Behavioural Disorders
- Registration Number
- ISRCTN39857520
- Lead Sponsor
- King's College London (UK)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 100
Consenting patients aged 16 years or over with a score of 13 or more on the Hamilton Rating Scale for Depression (HAM-D), 9 or more on the Beck Depression Inventory and who have been compliant with a specific serotonin reuptake inhibitor at a standard dose for at least four weeks (as ascertained by self report questionnaire) will be invited to participate in the study.
1. Temporary registrations
2. Under 16 years
3. Currently receiving psychological therapies (cognitive behavioural therapy, problem solving therapy, interpersonal therapy)
4. Other psychotropic medications apart from benzodiazepines
5. Case note diagnosis of schizophrenia or bipolar affective disorder
6. Currently being treated for drug or alcohol dependence
7. Suicidal patients
8. Psychotic depression as evidenced by delusions and/or hallucinations
9. Patient treated by secondary psychiatric services
10. Non-English speaking
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To determine the feasibility of conducting a larger randomised controlled trial to examine clinical effectiveness of switching an antidepressant medication to another from a different antidepressant class in primary care patients with treatment-refractory depression.
- Secondary Outcome Measures
Name Time Method 1. Whether demographic variables, social adversity, life events, physical health and disability, are associated with outcome<br>2. Whether patient and doctor beliefs about depression and antidepressant medication are associated with outcome