Outcomes of Neoadjuvant Therapy for Rectal Cancer in a Tertiary Asian Institute

Completed

• Conditions: Rectal Cancer; Oncology

• Registration Number: NCT05607186
• Lead Sponsor: Singapore General Hospital

Brief Summary

This is a retrospective cohort study that aims to evaluate the correlation of magnetic resonance tumour regression grade (mrTRG) and pathological TRG (pTRG) of locally advanced rectal cancer after neoadjuvant long course chemoradiotherapy as well as the prognostic value of mrTRG on survival.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-01-01
• Primary Completion: 2016-12-31
• Study Completion: 2019-12-31
• Status Verified: 2022-10
• Study First Submitted: 2022-10-31
• Study First Submitted QC: 2022-10-31
• Last Update Submitted: 2022-10-31
• Study First Posted: 2022-11-07
• Last Update Posted: 2022-11-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 59

Inclusion Criteria

• Rectal cancer
• At least 1 high risk feature on MRI
• Undergo long course neoadjuvant chemoradiotherapy (LCCRT)

Read More

Exclusion Criteria

• metastatic disease
• Patients who undergo short course radiotherapy
• Patients without a repeat MRI after completion of LCCRT

Read More

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Correlation between mrTRG and pTRG	Between 1 Jan 2011 to 31 Dec 2016

Secondary Outcome Measures

Name	Time	Method
Prognostic value of mrTRG on survival outcomes of rectal cancer patients	Between 1 Jan 2011 to 31 Dec 2016