Early Detection of Sepsis and Severe Sepsis in Patients by Point of Care Diagnostics (SEPTOMETER)

• Conditions: A41; Other sepsis

• Registration Number: DRKS00029970
• Lead Sponsor: niversitätsmedizin Mannheim Klinik für Anästhesie und Operative Intensivmedizin

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2019-06-30
• Study Start: 2022-10-13
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

Patients with SIRS and patients with sepsis in the Surgical Intensive Care Unit.

Exclusion Criteria

age <18 years, immunosuppression, pregnancy, need for ECMO therapy and neurosurgical main diagnosis

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Early detection of sepsis in SIRS patients based on progranulin plasma concentration with a specificity = 73% and a sensitivity of = 80% at least 6 h before sepsis diagnosis supported by standard laboratory chemistry tests.

Secondary Outcome Measures

Name	Time	Method
Early detection of severe sepsis based on s-adenosylhomocysteine plasma concentration in patients with sepsis with a specificity = 73% and a sensitivity of = 80% at least 6 hours before clinical manifestation of organ dysfunction.