Effects of recreational nitrous oxide use on psychomotor functioning related to driving performance - psychomotor effects of nitrous oxide

niversiteit Maastricht0 个研究点目标入组 40 人开始时间: 待定最近更新: 2024年4月15日

适应症

试验速览

暂无简介。

•- Age 18-64
•- being in possession of a valid driver's licence (in the Netherlands)
•- Being in good physical and mental health as determined by a medical
•questionnaire and medical examination by a physician.
•- Have experience with the use of nitrous oxide ( >=1 moment in the past with at
•least 1x >=2 consecutive doses).
•- Experience with the method of administration (100% N2O bolus via balloon
•inhalation).
•- Be fully vaccinated against sars-cov-2 at least 14 days prior to the first
•physical encounter.
•- Applicants who are not or incompletely vaccinated for sars-cov-2 can enroll
•if they are willing to wear a face mask typ IIR during each visit (with the
•exception of during drug administration)

•-use of nitrous oxide > 10 different times in the past year and/or have used
•>10 recreational doses (i.e. >10 balloons filled with 3 - 8 liters, 100%
•nitrous oxide) per time. These limits describe 80% of recreational users (van
•Amsterdam et al., 2015). Adherence to these limits avoids the inclusion of
•excessive users whose psychomotor functioning may be impaired by neuropathy
•associated with excessive use. - Recent use of sedating, stimulating or
•dissociating drugs. This is assessed by questioning and possibly requesting
•patient records from GPs. - Recent use of other common intoxicants determined
•through a urine test at the start of the training and test days (Surestep*
•urine drug screen casette for amphetamines, benzodiazepines, cocaine,
•methamphetamines, morphine, THC). - Recent use of alcohol as determined by a
•positive breath test. - Excessive use of alcohol (>=21 standard glasses per week
•for men or >=14 standard glasses per week for women) - Pregnancy (determined by
•Alere* urine hCG test at start of first day of testing) and/or not using any
•contraceptives for women of childbearing potential - Latex allergy.

发起方