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Clinical Trials/NCT07012083
NCT07012083CompletedNot Applicable

Egyptian Doctors' Adherence to Anti-rabies Post-exposure Prophylactic Protocols; A Survey Study

Tanta University1 site in 1 country214 target enrollmentStarted: June 1, 2025Last updated:
Conditions

Trial Snapshot

Phase
Not Applicable
Status
Completed
Enrollment
214
Locations
1
Primary Endpoint
Adherence to Anti-rabies PEP Guidelines

Study Overview

Brief Summary

This study aims to investigate physicians' adherence to Advisory Committee on Immunization Practices (ACIP) guidelines regarding Anti-rabies post-exposure prophylaxis in Egypt.

Detailed Description

There is no known effective treatment for rabies, and virtually all cases are fatal. Although the prognosis is poor in patients who develop rabies, the disease is usually preventable with proper wound care and post-exposure prophylaxis. Following a thorough risk assessment, the decision to initiate rabies post-exposure prophylaxis should be made. The risk assessment should consider the type of exposure, local rabies epidemiology in animals, vaccination history of the animal, circumstances of the exposure incident, and the availability of the animal for observation or rabies testing .

The World Health Organization (WHO) and the Advisory Committee on Immunization Practices (ACIP) have adopted guidelines for starting post-exposure prophylaxis (PEP) against rabies. The decision to start Anti-Rabies PEP is usually made in primary health care units or emergency departments .

Lack of adherence to these guidelines might result in unnecessary costs and medical risks, such as injection site reactions and systemic hypersensitivity reactions . This malpractice of inappropriate anti-rabies PEP prescription is not uncommon.

Study Design

Study Type
Observational
Observational Model
Cohort
Time Perspective
Cross Sectional

Eligibility Criteria

Ages
18 Years to — (Adult, Older Adult)
Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • •Physicians who treat patients with animal bites potentially requiring post-exposure anti-rabies prophylaxis. The sample will include emergency physicians, general practice or family physicians, and surgeons of both sexes, with varying degrees of experience and post-graduate clinical training.

Exclusion Criteria

  • •Incomplete record filling

Outcomes

Primary Outcomes

Adherence to Anti-rabies PEP Guidelines

Time Frame: 6 months

This study aims to investigate physicians' adherence to the Advisory Committee on Immunization. Practices (ACIP) guidelines regarding Anti-rabies post-exposure prophylaxis in Egypt. This will be through a score given for the correct response to the case-based questionnaire. This questionnaire include 10 case-based scenarios where anti-rabies post-exposure prophylaxis may or may not be indicated as per ACIP guidelines. True response will be scored 1, wrong response will be scored 0 with maximum total score of 10. Higher score reflects better adherence to guidelines recommendations \& vice versa.

Secondary Outcomes

  • Health & Economic burden of such malpractice(9 months)

Investigators

Sponsor Class
Other
Responsible Party
Principal Investigator
Principal Investigator

Mohamed Ezzat Nasreddin

Lecturer of Emergency Medicine

Tanta University

Study Sites (1)

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