NCT01189591已完成不适用
Slow-wave Sleep Deprivation as a Possible Treatment for Major Depressive Disorder
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 25
- 试验地点
- 2
- 主要终点
- Hamilton Depression Scale
研究概览
简要总结
Sleep deprivation can acutely reverse depressive symptoms in patients with major depression. Although underlying mechanisms of the antidepressant action in sleep deprivation are unclear, many of these observations can be explained by abnormal slow wave homeostasis. This study will test the prediction that selectively reducing slow waves during sleep (slow wave deprivation; SWD), without disrupting total sleep time, will yield an antidepressant effect.
详细描述
see above
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- Single
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Among the inclusion criteria will be:
- •age range 18-35 years
- •right handedness
- •major depressive disorder according to DSM-IV (Diagnostic and Statical Manual-Revision 4) criteria (as determined by the Structured Clinical Interview for Diagnostic and Statical Manual-Revision 4), with Hamilton Rating Scale for *Depression scores of at least 18 on the first 17 items
- •no psychotropic medications for at least 4 weeks
- •no joint and muscular di
- •normal hearing
- •regular bedtimes and sleep duration, no time zone shifts in the last three weeks.
排除标准
- •Diabetes requiring insulin treatment
- •A serious heart disorder or subjects who have had a heart attack within the last 3 months
- •A diagnosis of cancer in the past 3 years and/or has active neoplastic disease
- •Clinically significant abnormalities on pre-study physical exam or physician evaluation
- •Subjects who meet DSM-IV (Diagnostic and Statical Manual-Revision 4) criteria for alcohol/drug abuse problems within the last six months or are currently using illegal drugs.
- •Female subjects of child-bearing potential who are pregnant or planning to become pregnant.
- •Women of child-bearing must be practicing a medically acceptable form of birth control.
- •Women of childbearing potential will be questioned about pregnancy status and form of birth control to be used at each visit.
- •Women who are unsure of their pregnancy status will be given a urine pregnancy test.
- •Subjects taking investigational medications
- •Subjects currently undergoing electroconvulsive therapy (ECT) or therapeutic transcranial magnetic stimulation (TMS).
- •Subjects who regularly perform night or late evening shift work (e.g. - "second" or "third" shifts) or have had travel with time zone shifts >3h in the last 3 weeks
研究组 & 干预措施
Sleep deprivation
Experimental
Slow-wave sleep deprivation for one night as an experimental treatment for major depressive disorder
干预措施: Slow-wave deprivation (Device)
结局指标
主要结局
Hamilton Depression Scale
时间窗: 24 hours
次要结局
- Inventory of Depressive Symptomology(24 hours)
研究者
研究点 (2)
Loading locations...
相似试验
招募中
不适用
Sleep Modulation to Treat DepressionHealthyMajor Depressive DisorderNCT06443216Christoph Nissen60
已完成
不适用
A Novel Use of a Sleep Intervention to Target the Emotion Regulation Brain Network to Treat Depression and AnxietyInsomniaDepressionNCT04424407Stanford University51
已完成
1 期
The Role of Dopamine Metabolism in the Antidepressant Effects of Sleep Deprivation and Sertraline in Depressed PatientsBipolar DisorderMajor Depressive DisorderNCT00581009University of California, Irvine49
已完成
不适用
Pilot Study: Establishing Glutamatergic Changes in Rapid Antidepressant Effects of Sleep DeprivationMajor Depressive DisorderNCT05893173University of Pennsylvania3
已完成
4 期
Sleep Deprivation Plus Paroxetine for Treating Major Depression in Elderly IndividualsDepressionNCT00178035University of Pittsburgh158