Daily variation of serum hepcidin levels in healthy volunteers during a day of iron-free diet and a day of iron free diet + oral iron supplementation: a cross over study
Completed
- Conditions
- IJzerstofwisselingsstoornisAnemia/Iron overload
- Registration Number
- NL-OMON34323
- Lead Sponsor
- niversitair Medisch Centrum Sint Radboud
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 25
Inclusion Criteria
Between 20-60 years of age
Fasted hepcidin levels > detection limit (0.5 nM)
Hb within reference range
ferritin, TIBC, CRP and ALAT within reference range
BMI<30
Exclusion Criteria
Red blood cell transfusions (> 2 units) in history
Chemotherapy in history
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Hepcidin </p><br>
- Secondary Outcome Measures
Name Time Method <p>Hemoglobin (Hb)<br /><br>Mean Corpuscular Volume (MCV)<br /><br>C-Reactive Protein (CRP)<br /><br>Iron (Fe)<br /><br>Total iron binding capacity (TIBC)<br /><br>Tranferrin Saturation (TS) --> calculated from iron and total iron binding<br /><br>capacity<br /><br>Ferritin<br /><br>Alanine Aminotransferase (ALAT) </p><br>