Effect of Beraprost sodium (Berasil®) on arterial stiffness in patients with type 2 diabetic nephropathy
- Conditions
- Diseases of The genitoruinary system
- Registration Number
- KCT0000691
- Lead Sponsor
- Seoul Metropolitan Government Seoul National University Boramae Medical Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot yet recruiting
- Sex
- All
- Target Recruitment
- 102
Aged 20 years or more and 75 years or less
Type 2 diabetes who is prescribed glucose-lowering agent or insulin
Estimated glomerular filtration rate (GFR) by isotope dilution mass spectrometry (IDMS)- Modification of Diet in Renal Disease (MDRD) equation 30 ml/min/1.73 m2 or more
verified 2 times or more of albuminuria 30 mg/g cr (or protein 300 mg/g cr)or more in a spot urine sample with interval of 1 week or more in recent 6 months
Patients whose blood pressure is 140/90 mmHg or less and did not receive a prescription for additional antihypertensive medication in recent 3 months
Patients who give written consent to this study by oneself
History of kidney transplantation
current advanced congestive heart failure (NYHA class III or more)
current uncontrolled arrhythmia
current advanced liver cirrhosis (Child-Pugh class C)
History of bleeding diathesis
current active infection or uncontrolled inflammatory disorders
History of cerebrovascular accident or myocardial infarction
current use of anticoagulant
current use of two or more antiplatelet agents
patients with advanced malignancy (life expectancy less than 6 months)
patients with uncontrolled diabetes (Hba1c more than 10%)
patients with severe anemia (Hb less than 8.0 g/dL)
female who are pregnant, trying to get pregnant or lactating
Genetic diseases such as galactose intolerance, lactose deficiency or glucose-galactose malabsorption
Study & Design
- Study Type
- Interventional Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Brachial ankle pulse wave velocity (PWV)
- Secondary Outcome Measures
Name Time Method Ankle brachial indices (ABI) ;Urine albumin creatinine ratio (UACR);IDMS MDRD estimated glomerular filtration rate (eGFR) ;Lipid profiles;Blood pressure