The Effect of Contrast Agent on Endothelial Function in Healthy Men
- Conditions
- Apoptosis of Endothelial Progenitor CellContrast AgentEndothelial FunctionCytokinesFree RadicalAlpha-lipoic Acid
- Registration Number
- NCT01895699
- Lead Sponsor
- Xiang Guang-da
- Brief Summary
Contrast medium is essential for diagnosis of many diseases. However, recent studies showed that contrast agents can induce renal injury and is associated with poor long-term clinical outcome, especially in diabetes. To date, no data are available on the relationship between contrast medium and endothelial function. Endothelial dysfunction is known to precede atherosclerosis and is considered a risk marker for future development of cardiovascular disease. Therefore, we hypothesized that contrast agents may induce endothelial dysfunction in healthy men. In addition, we hypothesized that contrast induced endothelial dysfunction via free radicals. Thus, we also test alpha-lipoic acid whether or not protect endothelial dysfunction induced by contrast agents.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 60
- healthy men
- 20 yr < = age < = 30 yr
- 20 < = body mass index < = 25
- age < 20 yr or > 30 yr
- dysfunction for liver, renal, and heart.
- other diseases such as diabetes, hypertension, thyroid disease
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method The endothelial dysfunction and the protective role of alpha-lipoic acid 6 months
- Secondary Outcome Measures
Name Time Method The apoptosis of endothelial progenitor cell 6 months
Trial Locations
- Locations (1)
Wuhan General Hospital
🇨🇳Wuhan, Hubei, China
Wuhan General Hospital🇨🇳Wuhan, Hubei, China