The Effect of Chlorella Vulgaris Supplementation on Oxidative Stress and Inflammatory Indices on Non-Alcoholic Fatty Liver Disease (NAFLD) Patients
Not Applicable
- Conditions
- non- alcoholic fatty liver disease.Fatty (change of) liver, not elsewhere classified
- Registration Number
- IRCT201202233320N7
- Lead Sponsor
- Tabriz University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 70
Inclusion Criteria
Liver steatosis on sonographic image; 20-50 years old; BMI>=30; moderately activity. Exclusion criteria: Alcohol intake more than 20g/d; gestation or lactation or Menopause; very active or inpatients; Cardiovascular disease; Pulmonary disease; renal disease; liver transplantation; other liver diseases and chronic or acute liver disease(Hepatitis A,B, ...); bilious impairments; cancers; inheritance diseases; using drugs like, insulin sensitivity enhancer, hepatotoxic drugs and estrogen.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Oxidative Stress Indicies. Timepoint: Beginning and end of the intervention. Method of measurement: TAC and ARE spectrophotometry, SOD and Gpx by Spectrometry and MDA thiobarbituric acid.;Inflammatory Indicies. Timepoint: Beginning and end of the intervention. Method of measurement: TNF-a and hs-CRP measurement with special kits.;Liver Enzyme (ALT,AST,ALP). Timepoint: Beginning and end of the intervention. Method of measurement: IFCC.;Liver steatosis. Timepoint: Beginning and end of the intervention. Method of measurement: Liver Sonography.
- Secondary Outcome Measures
Name Time Method Anthropometry. Timepoint: Begining and end of intervention. Method of measurement: Scale and meter.;Energy and nutrient intake. Timepoint: beginning, fourth week and end of the intervention. Method of measurement: Dietary record and food frequency questionnaire.