Prevention of Familial Risk of Colorectal Carcinoma
- Conditions
- C18C19C20D12Malignant neoplasm of colonMalignant neoplasm of rectosigmoid junctionMalignant neoplasm of rectumBenign neoplasm of colon, rectum, anus and anal canal
- Registration Number
- DRKS00015097
- Lead Sponsor
- Kassenärztliche Vereinigung Bayerns
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 25848
Inclusion Criteria
25 -> 50 year-old persons of both genders, with and without family history of CRC, who gave their written consent to participate in the project
Exclusion Criteria
Individuals for whom adequate CRC related screening measures already exist are excluded from the study. In particular, patients with an increased risk of CRC due to a known disease (family history of adenomatous polyposis, chronic inflammatory bowel diseases (ulcerative colitis, Chron's disease)) or with a previous diagnosis of CRC will be excluded, as well as patients over 50 years of age for whom CRC screening already exists.
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The incidence of adenoma and of CRC in study participants who undergo one of the proposed screening options will be measured in the context of this screening option. <br>The incidence of adenoma and of CRC in study participants who do not participate in any screening measures and in those who do not participate in the program will be estimated based on administrative health records during the project period. The statistical analysis will take the difference in detection probabilities of adenoma and of CRC in the different groups in account. <br>
- Secondary Outcome Measures
Name Time Method - participation rate<br>- number of complications arising in the screening colonoscopies in the program<br>- positive predictive value of iFOBT (immunological fecal occult blood test): frequency of true and false positive findings