NCT03112512已完成不适用
A Comparison of Optimal Positive End-expiratory Pressure Determination Guided by Electrical Impedance Tomography and Protective Ventilation Tool by G5(MV) in Moderate and Severe Acute Respiratory Distress Syndrome Patients
Mei-Yun Chang1 个研究点 分布在 1 个国家目标入组 88 人开始时间: 2017年4月20日最近更新:
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 88
- 试验地点
- 1
- 主要终点
- Respiratory system parameter
研究概览
简要总结
To Select the Optimal Positive End-expiratory Pressure in Moderate and Severe Acute Respiratory Distress Syndrome Patients by Using:
- the novel Non-invasive Electrical Impedance Tomography Guided Method
- the Protective ventilation tool G5(MV)
详细描述
- To titrate PEEP guided by EIT. A global inhomogeneity (GI) index and regional compliance based on EIT were developed to quantify the tidal volume distribution within the lung. The aim of this study was to test the feasibility of optimizing PEEP with respect to ventilation homogeneity using the GI index and regional compliance.
- To titrate PEEP with the Protective Ventilation Tool by G5(MV). The new generation of ventilator will deliver an optimal PEEP on ARDS patients based on their status automatically.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •ARDS patients
- •Transferred from FEMH emergency room or Ward into the medical intensive care unit.
- •Patients with invasive mechanical ventilation
- •Patient, agent or consent of families learn about and subjects were willing to sign the consent form.
排除标准
- •burning electric knife used
- •pacemaker used
- •Large area wound is used gauze to cover
- •Wound or burn injuries of the chest wall.
- •Patients included conditions are not met.
研究组 & 干预措施
EIT
Experimental
PEEP titration is performed where EIT is measured at the same time. After PEEP titration, EIT data is analyzed. Global inhomogeneity index and regional compliance based on EIT are calculated. PEEP level is selected when ventilation distribution is most homogeneous.
干预措施: optimal PEEP guided by EIT (Device)
G5 VENTILATOR
Experimental
Protective Ventilation Tool by G5(MV) to determine the optimal PEEP on ARDS patients. The results are delivered by the ventilator automatically.
干预措施: optimal PEEP guided by G5 ventilator (Device)
结局指标
主要结局
Respiratory system parameter
时间窗: 48 hrs
Compliance
次要结局
- Respiratory system parameter(48 hrs)
- MV day(64 days)
研究者
Mei-Yun Chang
Principal Investigator
Far Eastern Memorial Hospital
研究点 (1)
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