CTRI/2014/10/005148CompletedPhase 4
Effect of Dexmedetomidine on cerebral blood flow auto-regulation in patients with intracranial tumours.
Sri Chitra Tirunal Institute for Medical Science and Technology0 sites30 target enrollmentStarted: TBDLast updated:
Trial Snapshot
- Phase
- Phase 4
- Status
- Completed
- Sponsor
- Enrollment
- 30
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Interventional
Eligibility Criteria
Inclusion Criteria
- •two groups (15 patients in each group)
- •Group I - patients with unilateral Glioma, Glascow coma scale 15, American society of anesthesiology Grading 1 and 2.
- •Group II - patients having no intracranial pathology ( patients posted for lumbar and thoracic spinal cord surgeries (laminectomy, discectomy), American society of anesthesiology Grading 1 and 2.
Exclusion Criteria
- •Patient refusal, American society of Anesthesiology (ASA) class 3 and above, Age less than 18 years and more than 35 years, Preoperative Glasgow coma scale (GCS) <15, Intracranial vascular abnormalities, Documented cases of Carotid stenosis, atherosclerosis, Infra tentorial / posterior fossa tumours, Emergency surgery, Preoperative heart rate <50 bpm, Systemic hypertension stage III & above, Heart block, Known allergy to Dexmedetomidine, Patient on beta blockers, Coronary artery disease, Left ventricular dysfunction,Pregnant or Nursing woman.
- •Antihypertensive medication with alpha-methyldopa, clonidine or other a2-adrenergic agonist, Vascular pathology ( Plaque, calcification, narrowing, stenosis, abnormal flow pattern ) identified during pre-induction sonography, Difficulty in localizing intracranial vasculature by TCCDI, Abnormal bone window, Participation in another drug study during the preceding 1 month period.
Investigators
Similar Trials
Completed
Not Applicable
The effects of dexmedetomidine on cerebral blood flow and cerebral metabolic rateTraumatic brain injury (TBI), cerebral blood flow (CBF) and cerebral metabolic rate (CMR)Injury, Occupational Diseases, PoisoningIntracranial injury, unspecifiedISRCTN57998533Shanghai Sixth People's Hospital (China)50
Recruiting
Not Applicable
Effects of dexmedetomidine on cerebral blood velocity in childreKCT0002528Yonsei University Health System, Severance Hospital62
Not yet recruiting
Phase 2
Effect of Dexmedetomidine on brain blood vessel related blood tests in abnormal brain blood vessel bleed patients undergoing surgery under general anesthesia.CTRI/2022/05/042738AIIMS
Active, not recruiting
Not Applicable
The effects of dexmedetomidine on cerebral autoregulation and cerebral oxygenation in subarachnoid haemorrhage patients.This study will be conducted on aneurysmal subarachnoid hemorrhage patients.EUCTR2012-000068-11-FITurku University Hospital15
Recruiting
Phase 3
The effect of dexmedetomidine on hemodynamic changes in patients undergoing coronary artery bypass graftcoronary artery bypass graft.Atherosclerosis of coronary artery bypass graft(s), unspecified, with unspecified angina pectorisI25.709IRCT20220316054311N1Vice-Chancellery for Research Hormozgan University of Medical Sciences72