Effect of Dexmedetomidine on brain blood vessel related blood tests in abnormal brain blood vessel bleed patients undergoing surgery under general anesthesia.
Phase 2
Not yet recruiting
- Conditions
- Health Condition 1: G94- Other disorders of brain in diseases classified elsewhere
- Registration Number
- CTRI/2022/05/042738
- Lead Sponsor
- AIIMS
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Not Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1.Patient who gives Informed Consent
2.Patients with anterior circulation aneurysms
3.WFNS grade 1 aneurysm
4.Age between 18-65 years
5.ASA grade 1 and 2
6.Both gender
7.MMSE 24-30
Exclusion Criteria
1.Patients not giving consent
2.Patients with posterior circulation aneurysm
3.Age <18 years and >65 years
4.ASA grade 3,4,5
5.Pregnant patients
6.WFNS grade 2,3,4
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1.Biomarker Serum IL6, CRP and S100-β levelsTimepoint: 24 hrs after surgery.
- Secondary Outcome Measures
Name Time Method 1.Detection of Mean flow velocity [MFV] in cm/sec in middle cerebral artery [MCA] using transcranial Doppler [TCD]Timepoint: 24 hrs after surgery.;2.Neurological outcome [using Mini Mental State Examination [MMSE]Score]Timepoint: 24 hrs after surgery.;3. Glasgow Outcome Scale Extended [GOSE]Timepoint: at discharge and 28 days