eft ventricular diastolic function in lean and overweight subjects.

Not Applicable

Completed

• Conditions: on-diabetic subjects with a spectrum of body mass ranging from lean (body mass index<25kg/m2) to overweight (BMI 25kg/m2 or greater); Non-diabetic subjects with a spectrum of body mass ranging from lean (body mass index<25kg/m2) to overweight (BMI 25kg/m2 or greater); Diet and Nutrition - Other diet and nutrition disorders

• Registration Number: ACTRN12605000298617
• Lead Sponsor: Professor Gerald F Watts

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2005-09-05
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

Subjects without diabetes (excluded by oral glucose tolerance test); lean subjects (BMI<25kg/m2) with waist circumference <94cm for men and <88cm for women; overweight subjects (BMI 25kg/m2 or greater) with waist circumference 94cm or greater for men and 88cm or greater for women.

Exclusion Criteria

Atrial fibrillation; abnormal thyroid function; history of cardiovascular disease (myocardial or cerebral ischaemia); other major systemic illness. Lean subjects: impaired glucose tolerance, blood pressure>140/80mmHg, fasting total cholesterol 6.0mmol/L or greater; fasting triglycerides 2.2mmol/L or greater; treatment for hypertension or dyslipidaemia. Overweight subjects: blood pressure 150/90mmHg or greater; fasting total cholesterol>7.0mmol/L; fasting triglycerides>4.0mmol/L.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Diastolic function as assessed by transthoracic cardiac ultrasound, employing a variety of echo-Doppler techniques. Echocardiography done at 1 timepoint.[Cross-sectional]

Secondary Outcome Measures

Name	Time	Method
Individual echo-Doppler parameters (including pulsed wave Doppler transmitral flow and tissue Doppler imaging).[Secondary outcomes measured only at one time point.];Non-invasive measures of arterial stiffness using pulse analysis techniques: central augmentation index and pulse wave velocity (Sphygmocor system, AtCor Medical); large (C1) and small (C2) artery compliance (PulseWave CR-2000 system, HDI).[Secondary outcomes measured only at one time point.]