Mood Effects of Serotonin Agonists
- Registration Number
- NCT03790358
- Lead Sponsor
- University of Chicago
- Brief Summary
The purpose of this study is to determine the effects of very low doses of serotonergic agonists on depressed mood in human volunteers.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 80
Inclusion Criteria
- English fluency
- High school level education
- BMI between 19 and 30
Exclusion Criteria
- Diagnosed medical condition
- women who are nursing, pregnant, or plan to become pregnant within 3 months
- History of psychotic disorder or family history of psychotic disorder
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description high dose Lysergic Acid Diethylamide 26ug dose of serotonin agonist Placebo Lysergic Acid Diethylamide Placebo low dose MDMA Lysergic Acid Diethylamide 6.5ug dose of serotonin agonist medium dose Lysergic Acid Diethylamide 13ug dose of serotonin agonist
- Primary Outcome Measures
Name Time Method Change From Baseline in Profile of Mood States (POMS) End of study (Baseline - time 0 and approximately 8 weeks later) The POMS measures individuals' mood states. This is a validated scale to measure positive and negative mood states. The POMS contains 30 items and assesses six identified mood factors: Tension-Anxiety, Depression-Ejection, Anger- Hostility, Vigor-Activity, Fatigue-Inertia, and Confusion-Bewilderment. Scoring of the instrument provides a global score of 0 to 120 or individual domain scores. Lower scores indicate better mood state. The POMS brief form is a simple self-rating instrument.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (2)
Matthew Bona
🇺🇸Chicago, Illinois, United States
University of Chicago
🇺🇸Chicago, Illinois, United States