Skip to main content
Clinical Trials/NCT06129721
NCT06129721CompletedNot Applicable

Emergent Stenting In Acute Vertebrobasilar Occlusions

Can Tho Stroke International Services Hospital2 sites in 1 country38 target enrollmentStarted: December 1, 2020Last updated:
Conditions

Trial Snapshot

Phase
Not Applicable
Status
Completed
Sponsor
Enrollment
38
Locations
2
Primary Endpoint
The favorable 3-month outcome rate

Study Overview

Brief Summary

In the acute posterior circulation strokes, the vertebrobasilar occlusions frequently related to worse outcomes than the anterior ones. However, few studies mentioned the benefit and safety of the emergent stenting in the successful recanalization at these complex occlusions. The investigators investigated whether the improvement of clinical outcome was achieved in postprocedural 3-month.

Detailed Description

Acute ischemic stroke in posterior circulation account for nearly 20 - 25%, in which large vessel occlusions (LVOs) occur 0.8% - 5.7%. Although mechanical thrombectomy (MT) has recently been the gold standard in LVOs treatment, the futile recanalization (defined as unfavorable outcome despite early successful recanalization of target artery) rate was showed in posterior circulation higher than in anterior one. Multiple randomized controlled trials (BEST, BASICS, BAOCHE, ATTENTION) have recently reported the benefit of endovascular treatment better than of standard medical treatment for acute vertebrobasilar occlusions stroke. Besides, up to 36% LVOs with underlying intracranial stenosis and 64% with tandem lesions occured in the acute vertebrobasilar stroke. This was a reason why emergent stenting was considered to support the successful recanalization in the setting of failure of mechanical thrombectomy. Moreover, the successful recanalization is one of the independent predictors of good outcomes. However, the use of the loading dose dual antiplatelet therapy and peri-procedural complications made the safety of emergent stenting remain uncertain. Therefore, we aimed to investigate whether the impact of emergent stenting on the improved clinical outcome in vertebrobasilar occlusions.

Study Design

Study Type
Interventional
Allocation
Na
Intervention Model
Single Group
Primary Purpose
Treatment
Masking
None

Eligibility Criteria

Ages
19 Years to 100 Years (Adult, Older Adult)
Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Age > 18 years old
  • Onset to treatment time < 24 hours
  • NIHSS ≥ 10
  • pc-ASPECTS ≥ 5 on MRI

Exclusion Criteria

  • Premorbid mRS > 2
  • Extensive, bilateral brain-stem infarction on neuroimaging
  • Cerebellar mass effect on neuroimaging

Outcomes

Primary Outcomes

The favorable 3-month outcome rate

Time Frame: 3 months

The favorable 3-month outcome rate was accessed by modified Rankin Score (mRS), which comprised of included good (mRS 0 - ≤ 2) and fair (mRS 3).

Secondary Outcomes

  • The symptomatic intracerebral hemorrhage rate(24 hours after emergent stenting)

Investigators

Sponsor
Can Tho Stroke International Services Hospital
Sponsor Class
Other
Responsible Party
Principal Investigator
Principal Investigator

Dr. Cuong Tran Chi

Director

Can Tho Stroke International Services Hospital

Study Sites (2)

Loading locations...

Similar Trials