Total and free serum Ropivacaine Concentrations for patients receiving Continuous Transversus Abdominis plane block for Postoperative analgesia after abdominal surgery: Pilot Study

Phase 4

Recruiting

• Conditions: ocal anaestetic concentration after a bolus followed by continuous infusion in TAP block; Local anaestetic concentration after a bolus followed by continuous infusion in TAP block; Anaesthesiology - Anaesthetics

• Registration Number: ACTRN12612000104853
• Lead Sponsor: Dr Sarika Kumar

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2012-01-23
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

Elective/Emergency abdominal surgery
Between 18 and 80 years of age
ASA less than 4
Adequate English language skills

Exclusion Criteria

1 Allergy to local anaesthetic
2 Pt refusal
3 ASA score > 4 (i.e 4,5)
4 Pregnancy
5 On regular opioid medication or any other medication for
chronic pain management.
6 Mental handicap or psychiatric condition precluding adequat
communication.
7 Patients taking ciprofloxacin & fluvoxamine (affects
the metabolism of LA)
8 Qt c interval > 0.45 sec in males and > 0.47 sec in females
9 Drugs affecting Qtc interval e.g. Haloperidol, Amiodarone,
Sotaol

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Total and free ropivacaine concentration will be analysed using High Performance Liquid Chromatograph(HPLC).[predose, 15 mins post 2nd bolus, 30 mins, 45 mins, 60 mins, 2hr, 4hr, 8hr, 12hr,24 hr, 48 hr]

Secondary Outcome Measures

Name	Time	Method
Serial ECG's will be done to monitor any arrhythmia & to measure QTc interval as a prolonged QT interval is a biomarker for ventricular tachyarrhythmias.[pre op, 6hrs post 2nd bolus, 12hrs, 24 hrs, 48hrs];patients will be observed for sign & symptoms of Local anesthetic toxicity in terms of: BP, HR & rhythum, peri oral / tongue numbness, any visual changes, muscle twitching, convulsions[15mins( 2nd bolus), 30mins, 45 mins, 60 mins, 2 hrs, 4hr, 8 hr, 12hr, 24hr & 48hr]