A Study to Learn About a New Medicine Called Vepdegestrant (ARV-471, PF-07850327) in People Who Have Advanced Metastatic Breast Cancer
- Conditions
- Advanced Breast Cancer
- Interventions
- Registration Number
- NCT05654623
- Lead Sponsor
- Pfizer
- Brief Summary
A study to learn about a new medicine called ARV-471 (PF-07850327) in people who have advanced metastatic breast cancer.
- Detailed Description
The purpose of this study is to learn about the safety and effects of the study medicine ARV-471 (PF-07850327, vepdegestrant) compared to fulvestrant (FUL) in participants with advanced breast cancer. Advanced breast cancer is difficult to cure or control with treatment. The cancer may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body, i.e. bones, lungs, brain, or liver. FUL is a medicine already used for treatment of breast cancer while ARV-471 is a new medicine.
This study is seeking participants with breast cancer who:
* have cancer that has come back in the place where it started or spread to nearby tissue, lymph nodes, or distant parts of the body.
* cannot be fully cured by surgery or radiation therapy. Radiation therapy is the use of high-energy radiation such as x-rays, gamma rays and other sources to kill cancer cells and shrink tumors.
* respond to hormonal or endocrine therapy (which target hormones and/or activity of hormone receptors) such as tamoxifen or aromatase inhibitors (this is called estrogen receptor positive disease)
* have received one line of CDK4/6 inhibitor therapy (for example palbociclib, ribociclib or abemaciclib) in combination with endocrine therapy (for example letrozole) for advanced cancer.
* are allowed up to one other endocrine therapy (for example exemestane) for advanced cancer.
Half of the participants will be given ARV-471 while the other half of the participants will be given FUL.
Participants who get ARV-471 will take ARV-471 by mouth with food, one time a day. During the first treatment cycle participants who will get FUL will be given FUL by shots into the muscles on Day 1 and again 2 weeks later. After the first month, FUL shots will be given on the first day of each new treatment cycle. One treatment cycle is 28 days.
Participants will receive the study medicine until their breast cancer worsens or side effects become too severe. Participants will have visits at the study clinic about every 4 weeks.
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 624
- Adult participants with loco-regional recurrent or metastatic breast disease not amenable to surgical resection or radiation therapy
- Confirmed diagnosis of ER+/HER2- breast cancer
- Prior therapies for locoregional recurrent or metastatic disease must fulfill all the following criteria:
- One line of CDK4/6 inhibitor therapy in combination with endocrine therapy. Only one line of CDK4/6 inhibitor is allowed in any setting.
- ≤ 1 endocrine therapy in addition to CDK4/6 inhibitor with ET
- Most recent endocrine treatment duration must have been given for ≥6 months prior to disease progression. This may be the endocrine treatment component of the CDK4/6 inhibitor line of therapy.
- Radiological progression during or after the last line of therapy.
- Measurable disease evaluable per Response Evaluation Criterion in Solid Tumors (RECIST) v.1.1 or non-measurable bone-only disease
- Eastern Cooperative Oncology Group (ECOG) performance status 0-1
- Participants should be willing to provide blood and tumor tissue
- Participants with advanced, symptomatic visceral spread, that are at risk of life-threatening complications in the short term
- Prior treatment with:
- ARV-471, fulvestrant, elacestrant, mTOR, PI3K, AKT pathway inhibitors, PARP inhibitor for any setting
- other investigational agents (including novel endocrine therapy any SERDs, SERCAs, CERANs) for any setting
- prior chemotherapy for advanced/metastatic disease
- Inadequate liver, kidney and bone marrow function
- Active brain metastases
- Participants with significant concomitant illness
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description ARV-471 ARV-471 - Fulvestrant Fulvestrant -
- Primary Outcome Measures
Name Time Method Progression Free Survival (PFS) From randomization date (every 8 weeks for the first 48 weeks and then every 12 weeks thereafter) to date of first documentation of progression OR death (approximately 2 years). Progression-free survival is defined as the time interval from the date of randomization to the date of first documented tumor progression determined by blinded independent central review (BICR) assessment as per Response Evaluation Criteria in Solid Tumors (RECIST 1.1) or death due to any cause, whichever come first.
- Secondary Outcome Measures
Name Time Method Objective Response Rate (ORR) From randomization date (every 8 weeks during the first 48 weeks and then every 12 weeks) to the date of progression OR death (approximately to 2 years). Objective response rate is defined as the proportion of participants who have a confirmed CR or PR, as best overall response assessed by BICR as per RECIST 1.1, from the date of randomization to the date of disease progression, death due to any cause, whichever occurs first.
QT Interval (QTc) From baseline to end of treatment (approximately 2 years). Triplicate 12-lead electrocardiogram (ECG) measurements (each recording separated by approximately 2 minutes) are performed.
Plasma Concentration Versus Time of ARV-471 From randomization date up to cycle 7 (each cycle is 28 days). Plasma concentrations of ARV-471
Health state utility and health status will be assessed using the European Quality of Life Group questionnaire with 5 dimensions and 5 levels per dimension (EQ-5D-5L) From screening and every cycle until cycle 6 (each cycle is 28 days), and then every other cycle until 28 days after the last dose (approximately 2 years). Change from baseline and time to deterioration between treatment comparison in Quality of Life using the EQ-5D 5L questionnaire.
Overall survival (OS) From randomization date (every 3 months) to date of death (approximately 3 years) Overall survival is defined as the time interval from the date of randomization to the date of documented death due to any cause.
Clinical Benefit Rate From randomization date (every 8 weeks during the first 48 weeks and then every 12 weeks) to the date of progression or death (approximately to 2 years). Clinical benefit rate is defined as the proportion of participants who have a confirmed CR, PR at any time, or SD or nonCR/non PD for at least 24 weeks determined by BICR assessment as per RECIST 1.1, from the date of randomization until disease progression, death due to any cause, whichever occurs first.
Number of participants with treatment emergent adverse events (TEAEs), serious adverse events (SAEs), electrocardiogram (ECG) and laboratory abnormalities From screening until 28 days after the last dose (approximately 2 years). Incidence of participants with TEAEs, SAEs ECGs and laboratory abnormalities. TEAE/SAE and laboratory abnormalities will be graded according to NCI CTCAE V5.
Duration of response (DR) From the date of the first objective response (every 8 weeks during the first 48 weeks and then every 12 week) to the date of disease progression or death (approximately to 2 years). Duration of response is defined as the time from first documented evidence of CR or PR until progressive disease (PD) as determined by BICR assessment as per RECIST 1.1 or death due to any cause, whichever occurs first.
Disease-related Quality of Life will be assessed using the European Organization for Research and Treatment of Cancer (EORTC) core quality of life questionnaire (QLQ-C30) From screening and every cycle until cycle 6 (each cycle is 28 days), and then every other cycle until 28 days after the last dose (approximately 2 years). Change from baseline and time to deterioration between treatment comparison in Quality of Life using the EORTC QLQ-C30 questionnaire.
Disease- and treatment-related Quality of Life will be assessed using the European Organization for Research and Treatment of Cancer (EORTC) breast cancer module (QLQ-BR23) questionnaire From screening and every cycle until cycle 6 (each cycle is 28 days), and then every other cycle until 28 days after the last dose (approximately 2 years). Change from baseline and time to deterioration between treatment comparison in Quality of Life Using the EORTC QLQ-BR23 (Breast) questionnaire.
Clinical Pain and its impact on functioning will be assessed using Brief Pain Inventory Short Form (BPI-SF) questionnaire. From screening and every cycle until cycle 6 (cycle=28 days) and then every other cycle until 28 days after the last dose (appr. 2 yrs).The modified BPI-SF (worst pain severity and pain interference) daily from baseline until the EOT (appr 2 yrs) Change from baseline and time to deterioration between treatment comparison in Brief Pain Inventory Short Form questionnaire.
circulating deoxyribonucleic acid (DNA) From baseline to end of treatment (approximately 2 years). Quantitative changes from baseline
Trial Locations
- Locations (398)
Morton Plant Hospital - BayCare Health System
🇺🇸Clearwater, Florida, United States
3T Radiology LLC
🇺🇸Coconut Creek, Florida, United States
Florida Cancer Specialists - South
🇺🇸Fort Myers, Florida, United States
Florida Cancer Specialists COL
🇺🇸Fort Myers, Florida, United States
Florida Cancer Specialists GLO
🇺🇸Fort Myers, Florida, United States
Lakeland Regional Cancer Center
🇺🇸Lakeland, Florida, United States
Broward P.E.T. Imaging Center
🇺🇸Lauderdale Lakes, Florida, United States
Florida Cancer Specialists NGD
🇺🇸Naples, Florida, United States
Florida Cancer Specialists NPW
🇺🇸Naples, Florida, United States
Florida Cancer specialists
🇺🇸Orange City, Florida, United States
Mid Florida Hematology and Oncology Center
🇺🇸Orange City, Florida, United States
POM MRI & Radiology Centers
🇺🇸Plantation, Florida, United States
BRCR Global
🇺🇸Plantation, Florida, United States
Florida Cancer Specialists PCH
🇺🇸Port Charlotte, Florida, United States
Florida Cancer Specialists SAC
🇺🇸Sarasota, Florida, United States
Florida Cancer Specialists SAD
🇺🇸Sarasota, Florida, United States
Impression Imaging
🇺🇸Tamarac, Florida, United States
Florida Cancer Specialist
🇺🇸Trinity, Florida, United States
Florida Cancer Specialists VIS
🇺🇸Venice, Florida, United States
Florida Cancer Specialists VHP
🇺🇸Venice, Florida, United States
Hope and Healing Cancer Services
🇺🇸Hinsdale, Illinois, United States
Northwest Oncology and Hematology
🇺🇸Rolling Meadows, Illinois, United States
Springfield Clinic Radiology - 800 Building
🇺🇸Springfield, Illinois, United States
Springfield Clinic
🇺🇸Springfield, Illinois, United States
Springfield Clinic Radiology - Main Campus
🇺🇸Springfield, Illinois, United States
Norton Cancer Institute - Downtown
🇺🇸Louisville, Kentucky, United States
Norton Cancer Institute, Downtown
🇺🇸Louisville, Kentucky, United States
Norton Hospital
🇺🇸Louisville, Kentucky, United States
Norton Cancer Institute, St Matthews Campus
🇺🇸Louisville, Kentucky, United States
Norton Women's & Children's Hospital
🇺🇸Louisville, Kentucky, United States
Norton Brownsboro Hospital
🇺🇸Louisville, Kentucky, United States
Norton Cancer Institute, Brownsboro Hospital Campus
🇺🇸Louisville, Kentucky, United States
University Medical Center New Orleans
🇺🇸New Orleans, Louisiana, United States
Louisiana State University Health Sciences Shreveport
🇺🇸Shreveport, Louisiana, United States
Hattiesburg Clinic Hematology/Oncology
🇺🇸Hattiesburg, Mississippi, United States
Mercy Clinic Oncology and Hematology
🇺🇸Ballwin, Missouri, United States
Saint Luke's Cancer Institute
🇺🇸Kansas City, Missouri, United States
Mercy Research - David C. Pratt Cancer Center
🇺🇸Saint Louis, Missouri, United States
Comprehensive Cancer Centers of Nevada
🇺🇸Las Vegas, Nevada, United States
Frank C Love Cancer Institute
🇺🇸Oklahoma City, Oklahoma, United States
Hightower Clinical Trial Services
🇺🇸Oklahoma City, Oklahoma, United States
SSM Health Medical Group - St Anthony
🇺🇸Oklahoma City, Oklahoma, United States
Providence Cancer Institute Franz Clinic
🇺🇸Portland, Oregon, United States
Providence Portland Medical Center
🇺🇸Portland, Oregon, United States
Tennessee Oncology, PLLC
🇺🇸Shelbyville, Tennessee, United States
Tennessee Oncology PLLC
🇺🇸Smyrna, Tennessee, United States
Sarah Cannon Research Institute- Pharmacy
🇺🇸Nashville, Tennessee, United States
SCRI Oncology Partners
🇺🇸Nashville, Tennessee, United States
Methodist Health System Clinical Research Institute
🇺🇸Dallas, Texas, United States
Valley Cancer Associates
🇺🇸Harlingen, Texas, United States
Methodist Richardson Cancer Center
🇺🇸Richardson, Texas, United States
Methodist Richardson Medical Center
🇺🇸Richardson, Texas, United States
The University of Texas Health Science Center at Tyler dba UT Health East Texas HOPE Cancer Center
🇺🇸Tyler, Texas, United States
University of Virginia Cancer Center
🇺🇸Charlottesville, Virginia, United States
University of Virginia Health System
🇺🇸Charlottesville, Virginia, United States
UVA Breast Care Center
🇺🇸Charlottesville, Virginia, United States
Hematology Oncology Associates of Fredericksburg
🇺🇸Fredericksburg, Virginia, United States
Bon Secours Memorial Regional Medical Center
🇺🇸Mechanicsville, Virginia, United States
Bon Secours Cancer Institute at St. Francis
🇺🇸Midlothian, Virginia, United States
Bon Secours St. Francis Medical Center
🇺🇸Midlothian, Virginia, United States
Bon Secours St. Mary's Hospital
🇺🇸Richmond, Virginia, United States
Providence Regional Cancer System - Aberdeen
🇺🇸Aberdeen, Washington, United States
Providence Regional Cancer System- Centralia
🇺🇸Centralia, Washington, United States
Providence Regional Cancer System - Lacey
🇺🇸Lacey, Washington, United States
UW Medicine Valley Medical Center
🇺🇸Renton, Washington, United States
Virginia Mason Medical Center
🇺🇸Seattle, Washington, United States
West Virginia University
🇺🇸Morgantown, West Virginia, United States
Centro de Oncología e Investigación de Buenos Aires
🇦🇷Berazategui, Buenos Aires, Argentina
Instituto de Oncología Angel H. Roffo
🇦🇷Caba, Buenos Aires, Argentina
Stat Research S.A.
🇦🇷Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina
Fundación Cenit Para La Investigación En Neurociencias
🇦🇷Caba, Ciudad Autónoma DE Buenos Aires, Argentina
Fundacion Estudios Clinicos
🇦🇷Rosario, Santa FE, Argentina
Sanatorio de La Mujer
🇦🇷Rosario, Santa FE, Argentina
Centro Oncologico Korben
🇦🇷Buenos Aires, Argentina
Centro de Educación Médica e Investigaciones clínicas "Dr. Norberto Quirno" (CEMIC)
🇦🇷Buenos Aires, Argentina
Fundación Respirar
🇦🇷Buenos Aires, Argentina
Focus CECIC
🇦🇷Ciudad Autónoma de Buenos Aires, Argentina
Instituto Medico Strusberg
🇦🇷Córdoba, Argentina
CIDIM-Centro Integral de Diagnostico por Imagenes Marchegiani
🇦🇷Córdoba, Argentina
Instituto Oulton
🇦🇷Córdoba, Argentina
Clínica Universitaria Reina Fabiola
🇦🇷Córdoba, Argentina
Centro Polivalente de Asistencia e Investigacion Clinica - CER San Juan
🇦🇷San Juan, Argentina
Coffs Harbour Health Campus
🇦🇺Coffs Harbour, New South Wales, Australia
Sunshine Coast University Private Hospital
🇦🇺Birtinya, Queensland, Australia
Princess Alexandra Hospital
🇦🇺Woolloongabba, Queensland, Australia
ICON Cancer Centre - Kurralta Park
🇦🇺Kurralta Park, South Australia, Australia
Icon Cancer Centre Hobart
🇦🇺Hobart, Tasmania, Australia
Cabrini Hospital -Brighton
🇦🇺Brighton, Victoria, Australia
Barwon Health
🇦🇺Geelong, Victoria, Australia
Cabrini Hospital - Malvern
🇦🇺Malvern, Victoria, Australia
Medizinische Universität Graz
🇦🇹Graz, Steiermark, Austria
LKH Hochsteiermark - Standort Leoben
🇦🇹Leoben, Steiermark, Austria
Klinikum Klagenfurt am Wörthersee
🇦🇹Klagefurt, Austria
Uniklinikum Salzburg
🇦🇹Salzburg, Austria
Antwerp University Hospital
🇧🇪Edegem, Antwerpen, Belgium
Cliniques universitaires Saint-Luc
🇧🇪Woluwe-Saint-Lambert, Bruxelles-capitale, Région DE, Belgium
Grand Hôpital de Charleroi
🇧🇪Charleroi, Hainaut, Belgium
UZ Leuven
🇧🇪Leuven, Vlaams-brabant, Belgium
Clinical Chc Montlégia
🇧🇪Liege, Belgium
Hospital Santa Rita de Cassia
🇧🇷Vitoria, Espírito Santo, Brazil
Hospital Nossa Senhora das Graças - Canoas
🇧🇷Canoas, RIO Grande DO SUL, Brazil
ONCOSITE - Centro de Pesquisa Clinica em Oncologia
🇧🇷Ijui, RIO Grande DO SUL, Brazil
Hospital Moinhos de Vento
🇧🇷Porto Alegre, RIO Grande DO SUL, Brazil
Centro Gaucho Integrado De Oncologia, Hematologia, Ensino E Pesquisa
🇧🇷Porto Alegre, RIO Grande DO SUL, Brazil
Hospital São Lucas da PUCRS
🇧🇷Porto Alegre, RIO Grande DO SUL, Brazil
Centro de Pesquisa Clínica - Área Administrativa
🇧🇷Porto Alegre, RIO Grande DO SUL, Brazil
Hospital Mae de Deus
🇧🇷Porto Alegre, RIO Grande DO SUL, Brazil
ANIMI - Unidade de Tratamento Oncologico
🇧🇷Lages, Santa Catarina, Brazil
Faculdade de Medicina do ABC
🇧🇷Santo André, SÃO Paulo, Brazil
A. C. Camargo Cancer Center
🇧🇷Sao Paulo, SÃO Paulo, Brazil
Fundação Faculdade Regional de Medicina de São José do Rio Preto
🇧🇷São José do Rio Preto, SÃO Paulo, Brazil
IBCC - Instituto Brasileiro de Controle do Câncer
🇧🇷São Paulo, Brazil
IBCC - Núcleo de Pesquisa e Ensino
🇧🇷São Paulo, Brazil
Instituto D'Or de Pesquisa e Ensino (IDOR)
🇧🇷São Paulo, Brazil
Complex Oncology Center - Burgas
🇧🇬Burgas, Bulgaria
Multiprofile Hospital for Active Treatment Dr. Tota Venkova AD
🇧🇬Gabrovo, Bulgaria
Specialized Hospital for Active Treatment of Oncology - Haskovo
🇧🇬Haskovo, Bulgaria
Complex Oncology Center - Plovdiv EOOD
🇧🇬Plovdiv, Bulgaria
Complex Oncology Center - Ruse EOOD
🇧🇬Ruse, Bulgaria
Complex Oncology Center - Vratsa
🇧🇬Vratsa, Bulgaria
Cross Cancer Institute
🇨🇦Edmonton, Alberta, Canada
BC Cancer Surrey
🇨🇦Surrey, British Columbia, Canada
The Moncton Hospital
🇨🇦Moncton, New Brunswick, Canada
Grand River Hospital
🇨🇦Kitchener, Ontario, Canada
Sunnybrook Research Institute
🇨🇦Toronto, Ontario, Canada
Unity Health Toronto, St. Michael's Hospital
🇨🇦Toronto, Ontario, Canada
McGill University Health Centre
🇨🇦Montréal, Quebec, Canada
Centre de Services Ambulatoires de St-Jerome
🇨🇦Saint-Jérôme, Quebec, Canada
Unité de Recherche Clinique du CISSS des Laurentides
🇨🇦St-Jerome, Quebec, Canada
Anhui Provincial Hospital
🇨🇳Hefei, Anhui, China
Anhui Provincial Cancer Hospital
🇨🇳Hefei, Anhui, China
Beijing Hospital
🇨🇳Beijing, Beijing, China
Cancer Hospital Chinese Academy of Medical Science
🇨🇳Beijing, Beijing, China
Fujian Medical University Union Hospital-1 Bingfanglou
🇨🇳Fuzhou Fujian, Fujian, China
The First People's Hospital of Foshan
🇨🇳Foshan, Guangdong, China
Sun Yat-sen University Cancer Center
🇨🇳Guangzhou, Guangdong, China
Guangxi Medical University Affiliated Tumor Hospital
🇨🇳Nanning, Guangxi, China
Harbin Medical University Cancer Hospital
🇨🇳Harbin, Heilongjiang, China
The First Affiliated Hospital of Henan University of Science &Technology
🇨🇳Luoyang, Henan, China
Wuhan Union Hospital Cancer Center
🇨🇳Wuhan, Hubei, China
Hubei Cancer Hospital
🇨🇳Wuhan, Hubei, China
Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School
🇨🇳Nanjing, Jiangsu, China
The Second Affiliated Hospital of Soochow University
🇨🇳Suzhou, Jiangsu, China
The First Affiliated Hospital of Nanchang University
🇨🇳Nanchang, Jiangxi, China
The Third Hospital of Nanchang
🇨🇳Nanchang, Jiangxi, China
The First Hospital of Jilin University
🇨🇳Changchun, Jilin, China
Jilin Province Tumor Hospital
🇨🇳Changchun, Jilin, China
The 2nd Affiliated Hospital of Dalian Medical University
🇨🇳Dalian, Liaoning, China
Centre Jean Perrin - Centre Régional de Lutte contre le Cancer d'Auvergne
🇫🇷Clermont-Ferrand, Puy-de-dôme, France
Sainte Catherine Institut du Cancer Avignon Provence
🇫🇷Avignon, Vaucluse, France
Bhakti Vedanta Hospital and Research Institute
🇮🇳Thane, Maharashtra, India
Institute of Post Graduate Medical Education and Research and Seth Sukhlal Karnani Memorial Hospital
🇮🇳Kolkata, WEST Bengal, India
Rabin Medical Center
🇮🇱Petah Tikva, Hamerkaz, Israel
Kaplan Medical Center
🇮🇱Rehovot, Hamerkaz, Israel
Yitzhak Shamir Medical Center
🇮🇱Zerifin, Hamerkaz, Israel
Istituto Nazionale Tumori IRCCS Fondazione Pascale
🇮🇹Napoli, Campania, Italy
Humanitas Istituto Clinico Catanese
🇮🇹Misterbianco, Catania, Italy
IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola
🇮🇹Bologna, Emilia-romagna, Italy
Azienda Ospedaliero Universitaria di Ferrara
🇮🇹Cona, Ferrara, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore
🇮🇹Roma, Lazio, Italy
Fondazione IRCCS San Gerardo dei Tintori
🇮🇹Monza, Lombardia, Italy
Azienda Ospedaliero Universitaria delle Marche
🇮🇹Ancona, Marche, Italy
Istituto di Candiolo IRCCS - Fondazione del Piemonte per l'Oncologia
🇮🇹Candiolo, Torino, Italy
Azienda Ospedaliero Universitaria Pisana
🇮🇹Pisa, Toscana, Italy
Ospedale Generale Provinciale Macerata
🇮🇹Macerata, Italy
Istituto Europeo di Oncologia IRCCS
🇮🇹Milano, Italy
Istituto Oncologico Veneto IRCCS
🇮🇹Padova, Italy
Aichi Cancer Center Hospital
🇯🇵Nagoya, Aichi, Japan
Nagoya University Hospital
🇯🇵Nagoya, Aichi, Japan
Nagoya City University Hospital
🇯🇵Nagoya, Aichi, Japan
Chiba cancer center
🇯🇵Chiba-shi, Chiba, Japan
National Cancer Center Hospital East
🇯🇵Kashiwa, Chiba, Japan
National Hospital Organization Hokkaido Cancer Center
🇯🇵Sapporo, Hokkaido, Japan
Kanagawa cancer center
🇯🇵Yokohama, Kanagawa, Japan
Osaka University Hospital
🇯🇵Suita, Osaka, Japan
Saitama Prefectural Cancer Center
🇯🇵Ina-machi, Saitama, Japan
Juntendo University Hospital
🇯🇵Tokyo, Japan
Tokyo Metropolitan Komagome Hospital, Department of Breast Surgery
🇯🇵Bunkyo-ku, Tokyo, Japan
Cancer Institute Hospital of JFCR
🇯🇵Koto-ku, Tokyo, Japan
Japanese Foundation for Cancer Research
🇯🇵Koto, Tokyo, Japan
National Center for Global Health and Medicine
🇯🇵Shinjuku City, Tokyo, Japan
Center Hospital of the National Center for Global Health and Medicine
🇯🇵Shinjyuku-ku, Tokyo, Japan
National Hospital Organization Kyushu Cancer Center
🇯🇵Fukuoka, Japan
Sagara Hospital
🇯🇵Kagoshima, Japan
Okayama University Hospital
🇯🇵Okayama, Japan
Gachon University Gil Medical Center
🇰🇷Namdong-gu, Incheon-gwangyeoksi [incheon], Korea, Republic of
National Cancer Center
🇰🇷Goyang-si, Kyǒnggi-do, Korea, Republic of
Seoul National University Bundang Hospital
🇰🇷Seongnam, Kyǒnggi-do, Korea, Republic of
Ajou University Hospital
🇰🇷Suwon, Kyǒnggi-do, Korea, Republic of
Korea University Anam Hospital
🇰🇷Seoul, Seoul-teukbyeolsi [seoul], Korea, Republic of
Seoul National University Hospital
🇰🇷Seoul, Seoul-teukbyeolsi [seoul], Korea, Republic of
Severance Hospital, Yonsei University Health System
🇰🇷Seoul, Seoul-teukbyeolsi [seoul], Korea, Republic of
Asan Medical Center
🇰🇷Seoul, Seoul-teukbyeolsi [seoul], Korea, Republic of
Gangnam Severance Hospital, Yonsei University Health System
🇰🇷Seoul, Seoul-teukbyeolsi [seoul], Korea, Republic of
Drammen Sykehus, Vestre Viken HF
🇳🇴Drammen, Buskerud, Norway
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie
🇵🇱Warszawa, Mazowieckie, Poland
Centrum Badań Klinicznych Jagiellońskie Centrum Innowacji sp. z o.o.
🇵🇱Kraków, Małopolskie, Poland
SP ZOZ Szpital Uniwersytecki w Krakowie
🇵🇱Kraków, Małopolskie, Poland
KLIMED Marek Klimkiewicz
🇵🇱Białystok, Podlaskie, Poland
COPERNICUS PL, Wojewodzkie Centrum Onkologii
🇵🇱Gdansk, Pomorskie, Poland
Centrum Terapii Wspolczesnej J. M. Jasnorzewska Spolka Komandytowo-Akcyjna
🇵🇱Lodz, Łódzkie, Poland
Puerto Rico Medical Research Center
🇵🇷Hato Rey, Puerto Rico
BRCR Global - Mayaguez Administrative Office
🇵🇷Mayaguez, Puerto Rico
BRCR Global - Mayagüez
🇵🇷Mayaguez, Puerto Rico
Hospital Oncológico Dr. Isaac González-Martinez
🇵🇷Rio Piedras, Puerto Rico
Pan American Center for Oncology Trials, LLC
🇵🇷Rio Piedras, Puerto Rico
Pan American Center for Oncology Trials- Hospital Oncologico
🇵🇷Rio Piedras, Puerto Rico
Auxilio Mutuo Cancer Center
🇵🇷San Juan, Puerto Rico
FDI Clinical Research
🇵🇷San Juan, Puerto Rico
Onkologicky ustav sv. Alzbety, s.r.o.
🇸🇰Bratislava, Slovakia
Narodny onkologicky ustav
🇸🇰Bratislava, Slovakia
Vychodoslovensky onkologicky ustav, a.s.
🇸🇰Kosice, Slovakia
Nemocnica s poliklinikou Stefana Kukuru Michalovce, a.s.
🇸🇰Michalovce, Slovakia
Nemocnica na okraji mesta n o
🇸🇰Partizanske, Slovakia
Fakultna nemocnica s poliklinikou J.A. Reimana Presov
🇸🇰Presov, Slovakia
Fakultna nemocnica Trnava
🇸🇰Trnava, Slovakia
Iatros International
🇿🇦Bloemfontein, FREE State, South Africa
15 Eton Road
🇿🇦Johannesburg, Gauteng, South Africa
Charlotte Maxeke Johannesburg Academic Hospital
🇿🇦Johannesburg, Gauteng, South Africa
WCR Office
🇿🇦Johannesburg, Gauteng, South Africa
Wits Clinical Research
🇿🇦Johannesburg, Gauteng, South Africa
Medical Oncology Centre of Rosebank
🇿🇦Johannesburg, Gauteng, South Africa
Cancercare Rondebosch Oncology
🇿🇦Cape Town, Western CAPE, South Africa
CHUAC-Hospital Teresa Herrera
🇪🇸A Coruña, A Coruña [LA Coruña], Spain
Hospital General Universitario de Elche
🇪🇸Elche, Alicante, Spain
Institut Català d'Oncologia (ICO) - Badalona
🇪🇸Badalona, Barcelona [barcelona], Spain
Parc de Salut Mar - Hospital del Mar
🇪🇸Barcelona, Barcelona [barcelona], Spain
Hospital Universitari Vall d'Hebron
🇪🇸Barcelona, Barcelona [barcelona], Spain
Institut Català d'Oncologia - L'Hospitalet
🇪🇸L'Hospitalet de Llobregat, Catalunya [cataluña], Spain
Hospital Universitario Donostia
🇪🇸San Sebastian, Gipuzkoa, Spain
Hospital Universitario Arnau de Vilanova de Lleida
🇪🇸Lleida, Lleida [lérida], Spain
Hospital Universitario 12 de Octubre
🇪🇸Madrid, Madrid, Comunidad DE, Spain
Hospital Universitario Virgen de la Victoria
🇪🇸Malaga, Málaga, Spain
Osi Bilbao-Basurto
🇪🇸Bilbao, PAÍS Vasco, Spain
Salut Sant Joan de Reus-Baix Camp (Edp)
🇪🇸Reus, Tarragona [tarragona], Spain
Hospital Universitario Virgen Nieves
🇪🇸Granada, Spain
Hospital Unviersitario Virgen Nieves
🇪🇸Granada, Spain
Hospital Universitario San Cecilio
🇪🇸Granada, Spain
Hospital Clinico San Carlos
🇪🇸Madrid, Spain
Hospital Universitario La Paz
🇪🇸Madrid, Spain
Hospital Universitario HM Sanchinarro
🇪🇸Madrid, Spain
Althaia, Xarxa Assistencial Universitària de Manresa
🇪🇸Manresa, Spain
Hospital Universitario Virgen Macarena
🇪🇸Sevilla, Spain
Hospital General Universitario de Valencia
🇪🇸Valencia, Spain
Hospital Universitari i Politecnic La Fe
🇪🇸València, Spain
Södersjukhuset
🇸🇪Stockholm, Stockholms LÄN [se-01], Sweden
Norrlands universitetssjukhus
🇸🇪Umeå, Västerbottens LÄN [se-24], Sweden
Sundsvalls Sjukhus
🇸🇪Sundsvall, Sweden
Tumor Zentrum Aarau
🇨🇭Aarau, Aargau, Switzerland
Kantonsspital Graubünden
🇨🇭Chur, Grisons, Switzerland
Kantonsspital Frauenfeld - Spital Thurgau AG
🇨🇭Frauenfeld, Thurgau, Switzerland
Kantonsspital Münsterlingen - Spital Thurgau AG
🇨🇭Münsterlingen, Thurgau, Switzerland
Ospedale Regionale Bellinzona e Valli
🇨🇭Bellinzona, Ticino, Switzerland
Kantonsspital Winterthur
🇨🇭Winterthur, Switzerland
Changhua Christian Hospital
🇨🇳Changhua County, Changhua, Taiwan
Chang Gung Memorial Hospital at Kaohsiung
🇨🇳Kaohsiung Niao Sung Dist, Kaohsiung, Taiwan
Chi Mei Medical Center
🇨🇳Tainan City, Tainan, Taiwan
Chi Mei Hospital - Liouying Branch
🇨🇳Tainan City, Tainan, Taiwan
Kaohsiung Medical University Chung-Ho Memorial Hospital
🇨🇳Kaohsiung, Taiwan
China Medical University Hospital
🇨🇳Taichung, Taiwan
National Cheng Kung University Hospital
🇨🇳Tainan, Taiwan
National Taiwan University Hospital
🇨🇳Taipei, Taiwan
Mackay Memorial Hospital
🇨🇳Taipei, Taiwan
Taipei Veterans General Hospital
🇨🇳Taipei, Taiwan
Koo Foundation Sun Yat-Sen Cancer Center
🇨🇳Taipei, Taiwan
Taipei Municipal Wan Fang Hospital
🇨🇳Taipei, Taiwan
Chang Gung Medical Foundation-Linkou Branch
🇨🇳Taoyuan, Taiwan
Hacettepe Universite Hastaneleri
🇹🇷Altindağ, Ankara, Turkey
Medipol Mega Universite Hastanesi
🇹🇷Istanbul, İ̇stanbul, Turkey
TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi
🇹🇷Istanbul, İ̇stanbul, Turkey
Acibadem Altunizade Hospital
🇹🇷İstanbul, İ̇stanbul, Turkey
Ege Universitesi Hastanesi
🇹🇷Izmir, İ̇zmir, Turkey
I.E.U. Medical Point Hastanesi
🇹🇷İzmir, İ̇zmir, Turkey
Adana Medical Park Seyhan Hastanesi
🇹🇷Adana, Turkey
Adana Sehir Egitim ve Arastirma Hastanesi
🇹🇷Adana, Turkey
Gulhane Egitim Arastirma Hastanesi
🇹🇷Ankara, Turkey
Memorial Ankara Hastanesi
🇹🇷Ankara, Turkey
Ankara Bilkent Şehir Hastanesi
🇹🇷Ankara, Turkey
Akdeniz Universitesi Hastanesi
🇹🇷Antalya, Turkey
Trakya University Medical Faculty Hospital
🇹🇷Edirne, Turkey
İnönü Üniversitesi Turgut Özal Tıp Merkezi Eğitim ve Araştırma Hastanesi
🇹🇷Malatya, Turkey
Samsun Medical Park Hastanesi
🇹🇷Samsun, Turkey
St Bartholomew's Hospital
🇬🇧London, London, CITY OF, United Kingdom
Churchill Hospital
🇬🇧Oxford, Oxfordshire, United Kingdom
Royal Blackburn Hospital
🇬🇧Blackburn, United Kingdom
The Beatson West of Scotland Cancer Centre
🇬🇧Glasgow, United Kingdom
The Christie Hospital NHS Foundation Trust
🇬🇧Manchester, United Kingdom
Florida Cancer Specialists BCC
🇺🇸Bradenton, Florida, United States
Florida Cancer Specialists LRS
🇺🇸Bradenton, Florida, United States
Florida Cancer Specialists NFM
🇺🇸Cape Coral, Florida, United States
Florida Cancer Specialists
🇺🇸Winter Park, Florida, United States
Ironwood Cancer & Research Centers
🇺🇸Scottsdale, Arizona, United States
Banner Gateway Medical Center
🇺🇸Gilbert, Arizona, United States
Banner MD Anderson Cancer Center
🇺🇸Gilbert, Arizona, United States
CBCC Global Research, Inc.
🇺🇸Bakersfield, California, United States
Comprehensive Blood and Cancer Center
🇺🇸Bakersfield, California, United States
California Cancer Associates for Research and Excellence, Inc. (cCARE)
🇺🇸Encinitas, California, United States
Orange Coast Memorial Medical Center
🇺🇸Fountain Valley, California, United States
California Cancer Associates for Research and Excellence
🇺🇸San Marcos, California, United States
California Research Institute
🇺🇸Los Angeles, California, United States
Providence Queen of the Valley Medical Center
🇺🇸Napa, California, United States
Providence Medical Foundation
🇺🇸Santa Rosa, California, United States
Providence Santa Rosa Memorial Hospital
🇺🇸Santa Rosa, California, United States
Providence Santa Rosa Memorial Hospital Laboratory
🇺🇸Santa Rosa, California, United States
Olive View-UCLA Medical Center
🇺🇸Sylmar, California, United States
TMPN Cancer Care research office
🇺🇸Torrance, California, United States
Torrance Memorial Physician Network / Cancer Care
🇺🇸Torrance, California, United States
Smilow Cancer Hospital Care Center at Fairfield
🇺🇸Fairfield, Connecticut, United States
Smilow Cancer Hospital at Yale-New Haven
🇺🇸New Haven, Connecticut, United States
Yale-New Haven Hospital
🇺🇸New Haven, Connecticut, United States
Smilow Cancer Hospital Care Center at North Haven
🇺🇸North Haven, Connecticut, United States
Smilow Cancer Hospital Care Center at Trumbull
🇺🇸Trumbull, Connecticut, United States
Florida cancer specialists
🇺🇸Altamonte Springs, Florida, United States
Florida Cancer Specialists BON
🇺🇸Bonita Springs, Florida, United States
Dartmouth-Hitchcock Medical Center
🇺🇸Lebanon, New Hampshire, United States
MSK Basking Ridge
🇺🇸Basking Ridge, New Jersey, United States
Astera Cancer Care
🇺🇸East Brunswick, New Jersey, United States
MSK Monmouth
🇺🇸Middletown, New Jersey, United States
Memorial Sloan Kettering - Bergen
🇺🇸Montvale, New Jersey, United States
Hematology Oncology Associates of CNY
🇺🇸Camillus, New York, United States
MSK Commack
🇺🇸Commack, New York, United States
Hematology-Oncology Associates of Central New York, PC
🇺🇸East Syracuse, New York, United States
MSK Westchester
🇺🇸Harrison, New York, United States
R.J. Zuckerberg Cancer Center
🇺🇸Lake Success, New York, United States
MSKCC Investigational Drug Service Pharmacy
🇺🇸Queens, New York, United States
Northern Westchester Hospital
🇺🇸Mount Kisco, New York, United States
Memorial Sloan Kettering Cancer Center
🇺🇸New York, New York, United States
MSK Evelyn H. Lauder Breast and Imaging Center
🇺🇸New York, New York, United States
Hematology Oncology Associates of Rockland
🇺🇸Nyack, New York, United States
Phelps Hospital
🇺🇸Sleepy Hollow, New York, United States
Hematology Oncology Associates of Central New York, PC
🇺🇸Syracuse, New York, United States
MSK Nassau
🇺🇸Uniondale, New York, United States
Summa Health - Cooper Cancer Center
🇺🇸Akron, Ohio, United States
University Hospitals Seidman Cancer Center at UH Avon Health Center
🇺🇸Avon, Ohio, United States
University Hospitals Ahuja Medical Center
🇺🇸Beachwood, Ohio, United States
University Hospitals Cleveland Medical Center
🇺🇸Cleveland, Ohio, United States
University Hospitals Seidman Cancer Center at UH Mentor Health Center
🇺🇸Mentor, Ohio, United States
UH Minoff Health Center at Chagrin Highlands
🇺🇸Orange Village, Ohio, United States
Cancer Centers of Southwest Oklahoma
🇺🇸Lawton, Oklahoma, United States
The First Affiliated Hospital of Jinzhou Medical University
🇨🇳Jinzhou, Liaoning, China
The First Hospital of China Medical University
🇨🇳Shenyang, Liaoning, China
Liaoning Cancer Hospital
🇨🇳Shenyang, Liaoning, China
The Second Affiliated Hospital of Xi'an Jiaotong University
🇨🇳Xi'an, Shaanxi, China
The First Affiliated Hospital of Xi'an Jiaotong University
🇨🇳Xi'an, Shaanxi, China
Shandong Cancer Hospital
🇨🇳Jinan, Shandong, China
Ruijin Hospital Shanghai Jiaotong University School of Medicine
🇨🇳Shanghai, Shanghai, China
Fudan University Shanghai Cancer Center
🇨🇳Shanghai, Shanghai, China
Tianjin Medical University Cancer Institute & Hospital
🇨🇳Tianjing, Tianjin, China
Yunnan Province Cancer Hospital
🇨🇳Kunming, Yunnan, China
Sir Run Run Shaw Hospital of Zhejiang University School of Medicine
🇨🇳Hangzhou, Zhejiang, China
Zhejiang Cancer Hospital
🇨🇳Hangzhou, Zhejiang, China
The Second Affiliated hospital of Zhejiang University school of medicine
🇨🇳Hangzhou, Zhejiang, China
Henan Cancer Hospital
🇨🇳Zhengzhou, China
Fakultní nemocnice Brno Bohunice
🇨🇿Brno, Brno-město, Czechia
Fakultni Thomayerova nemocnice
🇨🇿Prague, Praha 4, Czechia
Fakultni nemocnice Bulovka
🇨🇿Prague, Praha 8, Czechia
Fakultni nemocnice Olomouc
🇨🇿Olomouc, Czechia
Fakultni nemocnice Kralovske Vinohrady
🇨🇿Praha 10, Czechia
Tampereen yliopistollinen sairaala
🇫🇮Tampere, Pirkanmaa, Finland
Vaasan Keskussairaala
🇫🇮Vaasa, Pohjanmaa, Finland
Oulun yliopistollinen sairaala
🇫🇮Oulu, Pohjois-pohjanmaa, Finland
Satakunnan Keskussairaala
🇫🇮Pori, Finland
Centre Georges François Leclerc
🇫🇷Dijon, Côte-d'or, France
Centre de Cancérologie du Grand Montpellier
🇫🇷Montpellier, Languedoc-roussillon, France
Institut de Cancérologie de l'Ouest
🇫🇷ANGERS cedex 02, Maine-et-loire, France
Centre Hospitalier Universitaire de Poitiers
🇫🇷Poitiers, Vienne, France
Henri Mondor Hospital
🇫🇷Créteil, Île-de-france, France
Universitaetsklinikum Freiburg
🇩🇪Freiburg, Baden-württemberg, Germany
Gynäkologie Kompetenzzentrum Stralsund
🇩🇪Stralsund, Mecklenburg-vorpommern, Germany
Onkologische Schwerpunktpraxis Kurfuerstendamm
🇩🇪Berlin, Germany
University Hospital of Patras
🇬🇷Patras, Achaḯa, Greece
Alexandra General Hospital of Athens
🇬🇷Athens, Attikí, Greece
Attikon General University Hospital
🇬🇷Chaidari/Athens, Attikí, Greece
University General Hospital of Heraklion
🇬🇷Heraklion, Irakleío, Greece
University General Hospital of Larissa
🇬🇷Larissa, Thessalía, Greece
Békés Megyei Központi Kórház Pándy Kálmán Tagkórház
🇭🇺Gyula, Békés, Hungary
Békés Vármegyei Központi Kórház Pándy Kálmán Tagkórház
🇭🇺Gyula, Békés, Hungary
Petz Aladar Egyetemi Oktato Korhaz
🇭🇺Gyor, Győr-moson-sopron, Hungary
Budapesti Uzsoki Utcai Kórház
🇭🇺Budapest, Hungary
City Cancer Centre - Vijayawada
🇮🇳Vijayawada, Andhra Pradesh, India
Hcg Pet Imaging Centre
🇮🇳Vijayawada, Andhra Pradesh, India
Max Super Speciality Hospital
🇮🇳New Delhi, Delhi, India
All India Institute of Medical Sciences
🇮🇳New Delhi, Delhi, India
Venkateshwar Hospital
🇮🇳New Delhi, Delhi, India
Indraprastha Apollo Hospitals
🇮🇳New Delhi, Delhi, India
Rajiv Gandhi Cancer Institute And Research Centre
🇮🇳New Delhi, Delhi, India
Artemis hospital
🇮🇳Gurgaon, Haryana, India
Tata Memorial Hospital
🇮🇳Mumbai, Maharashtra, India
HCG Manavata Cancer Centre
🇮🇳Nashik, Maharashtra, India
Apex Wellness Hospital
🇮🇳Nashik, Maharashtra, India
Sahyadri Super Speciality Hospital, Hadapsar
🇮🇳Pune, Maharashtra, India
Samsung Medical Center
🇰🇷Seoul, Seoul-teukbyeolsi [seoul], Korea, Republic of
The Catholic Univ. of Korea Seoul St. Mary's Hospital
🇰🇷Seoul, Seoul-teukbyeolsi [seoul], Korea, Republic of
Ewha Womans University Mokdong Hospital
🇰🇷Seoul, Seoul-teukbyeolsi [seoul], Korea, Republic of
Cryptex Investigación Clínica S.A. de C.V.
🇲🇽Cuauhtémoc, Ciudad De México, Distrito Federal, Mexico
Boca Clinical Trials Mexico S.C.
🇲🇽Guadajalara, Jalisco, Mexico
Centro de Investigacion Clinica de Oaxaca
🇲🇽Oaxaca, Mexico
Akershus Universitetssykehus
🇳🇴Lorenskog, Akershus, Norway