Familial B-cell Lymphoproliferative Disorders

Not yet recruiting

• Conditions: Monoclonal B-Cell Lymphocytosis; Chronic Lymphocytic Leukemia; Premalignant; Lymphoproliferative Disorders
• Interventions: Other: No intervention

• Registration Number: NCT05718986
• Lead Sponsor: University of Haifa

Brief Summary

This study investigates families with at least two cases of B-cell lymphoproliferative disorders (LPD), and evaluates the prevalence of LPD in families, the relationship between medical history, genetic factors, and the risk of familial LPD, and various clinical outcomes for these families in a multiethnic population of Jews and Arabs in Israel.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2023-01-30
• Study First Submitted QC: 2023-01-30
• Study First Posted: 2023-02-08
• Status Verified: 2024-05
• Last Update Submitted: 2024-05-07
• Last Update Posted: 2024-05-08
• Study Start: 2024-06
• Primary Completion: 2028-12
• Study Completion: 2040-12

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 1000

Inclusion Criteria

• Patient inclusion criteria:

Patients must have LPD and must have a family history of LPD. LPD patients who signed an informed consent to participate in the study.

Criteria for the inclusion of relatives of patients:

Relatives must be related by blood to LPD patients or unrelated (for control group).

Relatives who signed an informed consent to participate in the study.

Exclusion Criteria

• Pregnant women, special populations and those lacking judgment will not be included

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Emek Medical Center	No intervention	Emek Medical Center
Beilinson Hospital	No intervention	Beilinson Hospital
Bnai Zion Medical Center	No intervention	Bnai Zion Medical Center
Sheba Medical Center	No intervention	Sheba Medical Center
Shamir Medical Center (Assaf Harofeh)	No intervention	Shamir Medical Center (Assaf Harofeh)
Soroka Medical Center	No intervention	Soroka Medical Center
Tel Aviv Sourasky Medical Center - Ichilov Hospital	No intervention	Tel Aviv Sourasky Medical Center - Ichilov Hospital
Galil Medical Center	No intervention	Galil Medical Center
Meir Medical Center	No intervention	Meir Medical Center
Rambam Medical Center	No intervention	Rambam Medical Center
Ziv Medical Center	No intervention	Ziv Medical Center
Kaplan Medical Center	No intervention	Kaplan Medical Center
Shaare Zdek Medical Center	No intervention	Shaare Zdek Medical Center
Hadassah Medical Center	No intervention	Hadassah Medical Center
Assuta Ashdod Hospital	No intervention	Assuta Ashdod Hospital

Primary Outcome Measures

Name	Time	Method
Prevalence of familial LPD in Israel	5 years
Association between medical history and genetic variants and the risk of familial LPD	5 years
Risk of clinical outcomes among familial LPD and family members	15 years