Familial B-cell Lymphoproliferative Disorders

Not yet recruiting

• Conditions: Monoclonal B-Cell Lymphocytosis; Chronic Lymphocytic Leukemia; Premalignant; Lymphoproliferative Disorders

• Registration Number: NCT05718986
• Lead Sponsor: University of Haifa

Brief Summary

This study investigates families with at least two cases of B-cell lymphoproliferative disorders (LPD), and evaluates the prevalence of LPD in families, the relationship between medical history, genetic factors, and the risk of familial LPD, and various clinical outcomes for these families in a multiethnic population of Jews and Arabs in Israel.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2023-01-30
• Study First Submitted QC: 2023-01-30
• Study First Posted: 2023-02-08
• Status Verified: 2024-05
• Last Update Submitted: 2024-05-07
• Last Update Posted: 2024-05-08
• Study Start: 2024-06
• Primary Completion: 2028-12
• Study Completion: 2040-12

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 1000

Inclusion Criteria

• Patient inclusion criteria:

Patients must have LPD and must have a family history of LPD. LPD patients who signed an informed consent to participate in the study.

Criteria for the inclusion of relatives of patients:

Relatives must be related by blood to LPD patients or unrelated (for control group).

Relatives who signed an informed consent to participate in the study.

Exclusion Criteria

• Pregnant women, special populations and those lacking judgment will not be included

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Prevalence of familial LPD in Israel	5 years
Association between medical history and genetic variants and the risk of familial LPD	5 years
Risk of clinical outcomes among familial LPD and family members	15 years