The Effects of Type of Exercise on Hepatic Fat Content and Metabolic Profiles in Non-alcoholic Fatty Liver Disease: A Randomized Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 38
- 试验地点
- 2
- 主要终点
- Hepatic fat content as assessed by the controlled attenuation parameter.
研究概览
简要总结
The type of physical activity such as, aerobic or resistant exercise required to reduce liver fat content in patient with non-alcoholic fatty liver disease (NAFLD) remains unclear. The purpose of this study is to determine whether aerobic exercise should provide improvement of hepatic fat content and inflammation as well as metabolic profiles and anthropometric parameters better than resistant exercise.
详细描述
Increasing prevalence of overweight and obese worldwide, non-alcoholic fatty liver disease (NAFLD) is commonly diagnosed in daily clinical practice. Weight reduction has been the only strategy established thus far to reduce hepatic lipid levels. Thus, dietary restriction and exercise focusing on weight reduction is recommended as the cornerstone for managing NAFLD. Recent reports have indicated that increased exercise greatly reduces hepatic fat accumulation and inflammation and the related oxidative stress levels outweigh those achieved by dietary restriction alone. Clear guidelines for such a "lifestyle physical activity" for NAFLD management are currently lacking. The type of physical activity such as, aerobic or resistant exercise required to reduce liver fat content remains unclear.The purpose of this study is to determine whether aerobic exercise should provide improvement of hepatic fat content and inflammation as well as metabolic profiles and anthropometric parameters better than resistant exercise.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Siriraj medical personals
- •Ultrasonography show liver steatosis by using ultrasound criteria
- •Transient elastography by using the controlled attenuation parameter show moderate degree of fatty accumulation in the liver
- •History of alcohol consumption in male <20 g/d, female <10 g/d
排除标准
- •Liver disease of other etiology
- •Medications that caused fatty accumulation in the liver
- •Treated with vitamin E or antidiabetic agents
- •Cardiopulmonary diseases or orthopedic conditions that are contraindicated for exercise
结局指标
主要结局
Hepatic fat content as assessed by the controlled attenuation parameter.
时间窗: 12 weeks
Hepatic fat content will be assessed with the controlled attenuation parameter (CAP) at baseline and the end of 12 weeks. The CAP measures ultrasonic attenuation in the liver at 3.5 MHz using signals acquired by the FibroScan® M probe based on vibration-controlled transient elastography. The final CAP value, which ranges from 100 to 400 decibels per metre (dB/m), is the median of individual measurements.
次要结局
- Liver fibrosis as assessed by vibration-controlled transient elastography.(12 weeks)
- Hepatic inflammation as assessed by serum levels of aspartate aminotransferase, alanine aminotransferase, ferritin and c-reactive protein.(12 weeks)
- Metabolic profiles assessed with the measurement of lipid profiles, plasma glucose, insulin and oral glucose tolerance test.(12 weeks)
- Anthropometry and bioelectrical impedance assessed by a bioelectrical fat analyzer.(12 weeks)
- Cardiorespiratory fitness as assessed with maximal oxygen uptake under treadmill test.(12 weeks)
研究者
Phunchai Charatcharoenwitthaya
Principle Investigator
Mahidol University