Fetal development of the left ventricular myocardium in left sided congenital heart defects

Recruiting

• Conditions: Aortic narrowing; 10010394

• Registration Number: NL-OMON45878
• Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 32

Inclusion Criteria

Pregnant women with:
- suspicion of CoA on fetal ultrasound:
* ventricular size disproportion (right to left ventricle ratio >1.3) and/or,
* great arterial size disproportion (pulmonary to aorta artery ratio >1.3) and/or,
* aortic arch hypoplasia
- age >=18 years of age
- 18-34 weeks of gestational age
- singleton or dichorionic twin pregnancy

Exclusion Criteria

- Fetal or neonatal diagnosis of other structural defects which could influence myocardial function, except for cardial defects leading to CoA. Cases with a premature closed foramen ovale, persistent vena cava superior sinistra, bicuspid aortic valve or small ventricular septum defect will be included as these conditions are common in CoA.
- Fetal chromosomal abnormalities identified by diagnostic testing
- Monochorionic twin pregnancy

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified