Effect of Different Anaesthesia Drugs on Function of Heart
- Conditions
- Health Condition 1: I251- Atherosclerotic heart disease of native coronary arteryHealth Condition 2: I350- Nonrheumatic aortic (valve) stenosisHealth Condition 3: I060- Rheumatic aortic stenosisHealth Condition 4: I712- Thoracic aortic aneurysm, withoutrupture
- Registration Number
- CTRI/2018/07/014997
- Lead Sponsor
- Post Graduate Institute of Medical Education and Research Chandigarh
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 61
Patients of either sex of the age group 18-65 years, undergoing Coronary Artery Bypass Grafting/ Valve replacement or repair surgery/ Combined Coronary Artery Bypass Grafting and Valve surgery/ Combined Valve and ascending aortic procedure/ surgery for correction or palliation of congenital heart diseases
1.Allergy to any of the drugs to be administered
2. Significant Mitral Annular Calcification
3. Regional dysfunction in the basal myocardial segments
4. Surgical rings or prosthetic mitral valves
5. Severe LV dysfunction (LVEF < 35%)
6. Pericardial disease
7. Poor echo window
8. Atrial fibrillation/Significant rhythm disturbance
9. H/o steroid use within last 6 months
10. H/o adrenal insufficiency
11. Significant Renal/Hepatic/CNS dysfunction
12. BMI > 35 kg/m2
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To evaluate and compare the effects of anaesthetic induction by Propofol, Etomidate and Sevoflurane on the echocardiographic parameters of Left Ventricular Function (Peak Global Longitudinal Strain, Septal and Lateral Mitral Annular S�) in adult patients undergoing cardiac surgeries.Timepoint: 1. Baseline <br/ ><br>2. Post Induction (Upon reaching target BIS of 50) <br/ ><br>3. Post Intubation (Within 1 minute after endotracheal intubation)
- Secondary Outcome Measures
Name Time Method