Prognostic Significance of Lymph Node Ratio in Rectal Cancer on Overall Survival: An Alternative Not a Substitute
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 229
- 试验地点
- 1
- 主要终点
- Overall Survival
研究概览
简要总结
This study was conducted to compare the significance of lymph node ratio and absolute count of positive lymph node count on overall survival in patients with rectal cancer who underwent resection with curative intent
详细描述
Retrospective cohort study carried on 229 patients with non-metastatic rectal cancer, admitted in tertiary hospitals along 10 years, between 2012 to 2022, and underwent radical resection surgery with curative intent.
Exclusion criteria included patients with familial adenomatous polyposis, multiple synchronous or metachronous rectal cancers, early post-operative recurrence or death within 3 months. Demographic, histopathological, follow up and outcome data were collected.
Demographics included age, gender, family history, and chief complaint at presentation. Histopathological data included tumor site, grade, vascular-perineural invasion, total number of lymph nodes removed, and positive lymph nodes.
Lymph node ratio was defined as the ratio of positive lymph nodes to the total number of retrieved lymph nodes in histopathology specimen. Survival was calculated for each patient based on time of surgery to time of death
Statistical analysis will be used to evaluate the effect of lymph node ratio on overall survival.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 19 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient with rectal cancer of stage I-III.
- •patients underwent radical resection with curative intent.
排除标准
- •Patients with Familial Adenomatous Polyposis, multiple synchronous or metachronous rectal cancers.
- •Early post-operative recurrence, or death within 3 months.
结局指标
主要结局
Overall Survival
时间窗: up to 10 years (From date of surgery to the date date of death)
Survival was calculated for each patient based on time of surgery to time of death.
次要结局
未报告次要终点
研究者
Abdallah Mohamed Taha Aly
Associate professor of General Surgry
South Valley University