Prognostic Significance of Lymph Node Ratio in Rectal Cancer on Overall Survival

Completed

• Conditions: Cancer, Rectum

• Registration Number: NCT05667259
• Lead Sponsor: South Valley University

Brief Summary

This study was conducted to compare the significance of lymph node ratio and absolute count of positive lymph node count on overall survival in patients with rectal cancer who underwent resection with curative intent

Detailed Description

Retrospective cohort study carried on 229 patients with non-metastatic rectal cancer, admitted in tertiary hospitals along 10 years, between 2012 to 2022, and underwent radical resection surgery with curative intent.

Exclusion criteria included patients with familial adenomatous polyposis, multiple synchronous or metachronous rectal cancers, early post-operative recurrence or death within 3 months. Demographic, histopathological, follow up and outcome data were collected.

Demographics included age, gender, family history, and chief complaint at presentation. Histopathological data included tumor site, grade, vascular-perineural invasion, total number of lymph nodes removed, and positive lymph nodes.

Lymph node ratio was defined as the ratio of positive lymph nodes to the total number of retrieved lymph nodes in histopathology specimen. Survival was calculated for each patient based on time of surgery to time of death

Statistical analysis will be used to evaluate the effect of lymph node ratio on overall survival.

Study Timeline

• Study Start: 2012-01-01
• Primary Completion: 2022-01-01
• Status Verified: 2022-12
• Study Completion: 2022-12-01
• Study First Submitted: 2022-12-19
• Study First Submitted QC: 2022-12-27
• Last Update Submitted: 2022-12-27
• Study First Posted: 2022-12-28
• Last Update Posted: 2022-12-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 229

Inclusion Criteria

• Patient with rectal cancer of stage I-III.
• patients underwent radical resection with curative intent.

Exclusion Criteria

• Patients with Familial Adenomatous Polyposis, multiple synchronous or metachronous rectal cancers.
• Early post-operative recurrence, or death within 3 months.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Overall Survival	up to 10 years (From date of surgery to the date date of death)	Survival was calculated for each patient based on time of surgery to time of death.

Trial Locations

Locations (1)

Qena Faculty of Medicine, South Valley University Hospitals; 🇪🇬 Qinā, Egypt