FDG-PET in the Diagnosis of Autoimmune Encephalitis
- Conditions
- Autoimmune Encephalitis
- Interventions
- Diagnostic Test: FDG-PET
- Registration Number
- NCT06019975
- Lead Sponsor
- University of Milano Bicocca
- Brief Summary
The goal of this retrospective observational study is to compare brain fluorodeoxyglucose-positron emission tomography (FDG-PET) of patients with autoimmune encephalitis, normal controls and patients with Alzheimer's disease (AD). The main question it aims to answer is:
•is there a specific pattern of brain metabolism in patients with autoimmune encephalitis Participants data and images will be retrospectively collected from hospital records, and FDG-PET images will be analyzed by means of statistical parametric mapping (SPM). Controls will be selected from validated public databases.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 90
- Diagnosis of autoimmune encephalitis according to clinical criteria
- Brain magnetic resonance imaging performed between clinical presentation and treatment
- Cerebrospinal fluid analysis performed between clinical presentation and treatment
- Brain FDG-PET performed between clinical presentation and treatment
- Autoantibodies testing performed between clinical presentation and treatment
- Refusal to give consent for the study
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Autoimmune Encephalitis patients FDG-PET Patients with autoimmune encephalitis admitted to the centers, who underwent a brain FDG-PET during the course of their disease trajectory.
- Primary Outcome Measures
Name Time Method SPM analysis of brain metabolic pattern up to 6 months Pattern of brain metabolism in patients with autoimmune encephalitis compared with healthy controls and patients with Alzheimer's disease, drawn from validated published databases
- Secondary Outcome Measures
Name Time Method Sensitivity of basal ganglia hypermetabolism up to 6 months Sensitivity of basal ganglia hypermetabolism for the diagnosis of autoimmune encephalitis
Diagnostic delay up to 6 months Comparison of diagnostic delay with and without FDG-PET
Trial Locations
- Locations (6)
Fondazione IRCCS Mondino
🇮🇹Pavia, Lombardia, Italy
Fondazione IRCCS San Gerardo dei Tintori
🇮🇹Monza, Monza E Della Brianza, Italy
Fondazione IRCCS Istituto Neurologico "Carlo Besta"
🇮🇹Milano, Italy
Azienda Sanitaria Universitaria Friuli Centrale
🇮🇹Udine, Friuli Venezia Giulia, Italy
Ospedale San Paolo
🇮🇹Milano, Italy
IRCCS Ospedale Policlinico San Martino
🇮🇹Genova, Liguria, Italy