Novel Method to Assess Hepatic Regeneration and Predict Hepatic Related Morbidity After Partial Hepatectomy

Not Applicable

Not yet recruiting

• Conditions: Liver Cancer Adult; Liver Regeneration

• Registration Number: NCT06681818
• Lead Sponsor: Englewood Hospital and Medical Center

Brief Summary

the investigators will pursue two specific aims: (1) to monitor the extent of heme oxygenase induction (by measuring endogenous CO production) in relationship to the extent of hepatic resection (2) to assess the production of CO in patients following liver resection and correlate these findings to the rate of liver regeneration and liver function.

Detailed Description

Not available

Study Timeline

• Status Verified: 2024-11
• Study First Submitted: 2024-11-06
• Study First Submitted QC: 2024-11-07
• Study First Posted: 2024-11-08
• Last Update Submitted: 2025-04-11
• Last Update Posted: 2025-04-13
• Study Start: 2025-12-01
• Primary Completion: 2039-01-01
• Study Completion: 2039-01-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 125

Inclusion Criteria

• Patient plans to have partial liver resection for primary liver pathology or metastatic disease
• Patient is able to comprehend and willing to sign the written consent form

Exclusion Criteria

• Patients < 18 years
• Patients identified as members of a vulnerable population, except women of child bearing potential with negative pregnancy test

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
correlation of carbon monoxide levels in exhaled breath with quantity and quality of liver regeneration	measurements will be taken pre, then 4 hours and 24 hours post resection	patients will be asked to donate exhaled breath into a smokerlyzer device

Secondary Outcome Measures

Name	Time	Method
level of carbon monoxide in exhaled air of patients	measurements will be taken pre, then 4 hours and 24 hours post resection	patients will be asked to donate exhaled breath into a smokerlyzer device
quantity of liver regeneration, liver volume (ml)	one and three months after resection	CT liver volumetric studies
quality of hepatic regeneration, normalized liver function	one and three months post resection	serum protein, albumin, AST and ALT, alkaline phosphatase, and bilirubin level

Trial Locations

Locations (1)

Englewood Hospital; 🇺🇸 Englewood, New Jersey, United States