Deep brain stimulation for obsessive-compulsive disorder
- Conditions
- obsessive-compulsive disorderOCD10037176
- Registration Number
- NL-OMON50163
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 40
We will include patients who meet the following inclusion criteria:
- Obsessive compulsive disorder according to DSM-5 criteria
- At least one of the following conditions is met: 1) Y-BOCS score >= 28; 2)
Y--BOCS >= 14 in case of solely obsessions or compulsions; 3) Suffering from
obsessions or compulsions for at least 8 hours a day (i.e. a score of 4 on item
1 or item 6 of the Y-BOCS)
- Treatment refractoriness is defined as failure of all of the following: 1) at
least 2 different types of SSRI*s; 2) clomipramine; 3) addition of an
antipsychotic to either an SSRI or clomipramine; 4) an adequate trial of
cognitive-behavorial therapy given by a therapist who has experience with OCD;
all treatments should be given at therapeutic dosages for adequate duration. On
clinical grounds, exceptions to this definition are allowed, but only after
consultation with the coordinating center.
- Age: 18 years or older
- Motivated and capable to make the frequent visits to the outpatient clinic,
which are necessary for parameter optimization and the CBT.
- Mentally capable to understand the consequences of the procedure and make his
or her own choice without coercion
- Primary diagnosis in psychotic spectrum
- Unstable multiple sclerosis (MS)
- Acute brain damage (eg. recent hemorrhage or stroke)
- General contraindications to have surgery
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Change in obsessive-compulsive symptomes (measured as a change of Y-BOCS score<br /><br>compared to baseline)</p><br>
- Secondary Outcome Measures
Name Time Method <p>Depressive symptoms (measured with the Hamilton Depression Rating Scale)<br /><br>Adverse events<br /><br>DBS settings<br /><br>Medication use</p><br>