Cyclic deep brain stimulation for obsessive-compulsive disorder
Completed
- Conditions
- obsessive-compulsive disorderOCD1000286110052863
- Registration Number
- NL-OMON55421
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 16
Inclusion Criteria
1) Subject has a primary diagnosis of OCD, which is treated with deep brain
stimulation at the AMC.
2) Subject has completed the period of optimization of DBS settings.
3) Subject has responded to DBS-treatment, defined as an improvement of >25% in
Y-BOCS at last follow-up compared to the pre-surgical baseline.
4) Subject has provided informed consent.
Exclusion Criteria
Subject is unwilling or unable to comply with all study-required follow-up
evaluations.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>1) Clinician rated symptom scales: Yale-Brown Obsessive-Compulsive Scale<br /><br>(Y-BOCS)<br /><br>2) Hamilton Depression Rating Scale (HDRS) and Hamilton Anxiety Scale (HAS)<br /><br>4) battery power and charging frequency<br /><br>5) adverse events</p><br>
- Secondary Outcome Measures
Name Time Method <p>1) Hamilton Depression Rating Scale (HDRS) and Hamilton Anxiety Scale (HAS)<br /><br>2) battery power and battery usage<br /><br>3) adverse events1) subtests of the Cambridge Neuropsychological Test Automated<br /><br>Battery (CANTAB) to assess cognitive functions<br /><br>4) resting state scalp EEG to assess amplitude, phase stability and<br /><br>cross-frequency coupling of cortical theta (~4 Hz), alpha (~10 Hz) and gamma<br /><br>(>40 Hz) EEG oscillations;<br /><br>5) EQ-5D and WHOQOL to assess quality of life.</p><br>